Allogeneic Transplantation From Related Haploidentical Donors
Completed
Stanford University
Phase 2
2000-08-01
The purpose of the study is to evaluate the feasibility and safety of transplanting CD34+
selected hematopoietic cells from a haploidentical related donor following a nonmyeloablative
regimen of total lymphoid irradiation (TLI) and antithymocyte globulin (ATG).
Low back pain is a common symptom that functionally disables many people. When the low back
pain is accompanied by pain that shoots down the leg, it is felt to be caused by a herniated
disc. We are conducting this study to determine if a powerful anti-inflammatory agent will
decrease the pain and functional impairment that is associated with this illness.
Do Corticosteroid Injections During Total Knee Replacement Improve Early Clinical Results?
Completed
St. Joseph's Health Care London
N/A
2006-03-01
Prior to surgery, a pharmacist will randomly assign participating patients to one of two
groups. One group will get an injection in the knee during surgery that contains medications
to limit pain and an antibiotic. A second group will get an injection in the knee during
surgery that contains the same pain medications and antibiotic along with a corticosteroid to
control inflammation. Corticosteroids are anti-inflammatory medications, not to be confused
with muscle-building anabolic steroids you may have heard about in the news. Each patient
will have an equal chance of being in either of the two groups. This study will test the
safety and efficacy of methylprednisolone acetate in the treatment of pain and inflammation
following total knee replacement.
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