Glutamine Supplementation to Prevent Death or Infection in Extremely Premature Infants
Completed
National Center for Research Resources (NCRR)
Phase 3
1999-07-01
This large multicenter double-masked clinical trial tested whether supplementation of
standard neonatal parenteral nutrition with glutamine would reduce the risk of death or
late-onset sepsis in extremely-low-birth-weight (ELBW, less than or equal to 1000 gm)
infants. Neonates with birth weights of 401-1000gm were randomized to standard TrophAmine or
TrophAmine supplemented with glutamine before 72 hours and continued until the infants are
tolerating full enteral feedings.
Glutamine Supplementation to Prevent Death or Infection in Extremely Premature Infants
Completed
NICHD Neonatal Research Network
Phase 3
1999-07-01
This large multicenter double-masked clinical trial tested whether supplementation of
standard neonatal parenteral nutrition with glutamine would reduce the risk of death or
late-onset sepsis in extremely-low-birth-weight (ELBW, less than or equal to 1000 gm)
infants. Neonates with birth weights of 401-1000gm were randomized to standard TrophAmine or
TrophAmine supplemented with glutamine before 72 hours and continued until the infants are
tolerating full enteral feedings.
Gluconeogenesis in Very Low Birth Weight Infants Who Are Receiving Nutrition By Intravenous Infusion
Unknown status
Baylor College of Medicine
N/A
1999-10-01
RATIONALE: Very low birth weight infants have problems maintaining normal blood sugar levels.
Gluconeogenesis is the production of sugar from amino acids and fats. The best combination of
amino acids, fat, and sugar to help very low birth weigh infants maintain normal blood sugar
levels is not yet known.
PURPOSE: Clinical trial to study how very low birth weight infants break down amino acids,
fat, and sugar given by intravenous infusion, and the effect of different combinations of
nutrients on the infants' ability to maintain normal blood sugar levels.
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