The Immune Response of Breast Cancer Patients Treated With Levobupivacaine Using Paravertebral or Superficial Chest Blocks
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University of Rijeka
N/A
2023-04-01
The use of regional anesthesia in breast surgery improves the postoperative outcome, reduces
the development of infection, and weakens the perioperative immunosuppressive response
associated with the response to surgical stress. The investigators hypothesize that the use
of propofol / paravertebral anesthesia and analgesia will be accompanied by a decrease in
serum proinflammatory cytokines and/or an increase in anti-inflammatory cytokines compared to
propofol / PECS 2 anesthesia and analgesia. The research will be on 100 respondents divided
into two groups. 0.5% levobupivacaine will be administered to both groups. Serum
concentrations of pro- and anti-inflammatory cytokines, and lymphocyte subpopulations 1h
before, 24h, and 48h after surgery will be measured. The investigators aim to compare the
effect of propofol / paravertebral and propofol / PECS 2 anesthesia and analgesia on serum
perioperative values of pro-inflammatory and anti-inflammatory cytokines to standardize
protocols and apply the best method of perioperative analgesia in breast cancer surgery.
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