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CLINICAL TRIALS PROFILE FOR PIFELTRO

All Clinical Trials for PIFELTRO

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT03886701 ↗	Doravirine, Rifapentine and Isoniazid Interaction	Completed	Merck Sharp & Dohme Corp.	Phase 1	2019-04-22	Drug therapy for persons living with human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) co-infected with latent tuberculosis infection (LTBI) is complex. Anti-tuberculosis drugs used to treat LTBI often induce drug metabolizing enzymes that share the same metabolic pathway as antiretroviral drugs used for those living with HIV/AIDS. This study evaluates the drug-drug interaction (DDI) potential of an antiretroviral drug when co-administered with a common anti-tuberculosis regimen of drugs.
NCT03886701 ↗	Doravirine, Rifapentine and Isoniazid Interaction	Completed	Walter K. Kraft	Phase 1	2019-04-22	Drug therapy for persons living with human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) co-infected with latent tuberculosis infection (LTBI) is complex. Anti-tuberculosis drugs used to treat LTBI often induce drug metabolizing enzymes that share the same metabolic pathway as antiretroviral drugs used for those living with HIV/AIDS. This study evaluates the drug-drug interaction (DDI) potential of an antiretroviral drug when co-administered with a common anti-tuberculosis regimen of drugs.
NCT03894124 ↗	Pharmacokinetics of Plasma Doravirine Once Daily Over 72 Hours Following Drug Intake Cessation in Healthy Volunteers	Completed	Imperial College London	Phase 1	2019-06-12	Study to assess the pharmacokinetics of plasma doravirine once daily over 72 hours following drug intake cessation at steady-state in healthy volunteers

Clinical Trial Conditions for PIFELTRO

Condition Name

Condition Name for PIFELTRO
Intervention	Trials
Human Immunodeficiency Virus	2
Drug Interaction Potentiation	1
HIV-1-infection	1

Condition MeSH

Condition MeSH for PIFELTRO
Intervention	Trials
Acquired Immunodeficiency Syndrome	2
Immunologic Deficiency Syndromes	2
HIV Infections	2

Clinical Trial Locations for PIFELTRO

Trials by Country

Trials by Country for PIFELTRO
Location	Trials
Spain	2
United Kingdom	2
United States	1

Trials by US State

Trials by US State for PIFELTRO
Location	Trials
Pennsylvania	1

Clinical Trial Progress for PIFELTRO

Clinical Trial Phase

Clinical Trial Phase for PIFELTRO
Clinical Trial Phase	Trials
Phase 4	1
Phase 3	1
Phase 1	2

Clinical Trial Status

Clinical Trial Status for PIFELTRO
Clinical Trial Phase	Trials
Completed	3
Not yet recruiting	1

Clinical Trial Sponsors for PIFELTRO

Sponsor Name

Sponsor Name for PIFELTRO
Sponsor	Trials
Merck Sharp & Dohme Corp.	3
Chelsea and Westminster NHS Foundation Trust	2
Walter K. Kraft	1

Sponsor Type

Sponsor Type for PIFELTRO
Sponsor	Trials
Other	6
Industry	3