Effect of Baclofen on Marijuana Withdrawal and Relapse
Completed
National Institute on Drug Abuse (NIDA)
Phase 2
2006-05-01
The purpose of this study is to determine if baclofen dose-dependently decreases marijuana's
direct effects and symptoms of marijuana withdrawal and thus decreases marijuana relapse.
Effect of Baclofen on Marijuana Withdrawal and Relapse
Completed
New York State Psychiatric Institute
Phase 2
2006-05-01
The purpose of this study is to determine if baclofen dose-dependently decreases marijuana's
direct effects and symptoms of marijuana withdrawal and thus decreases marijuana relapse.
The purpose of this study is determine if subjects with alcohol withdrawal who receive oral
baclofen, plus standard benzodiazepine therapy, will experience less severe withdrawal
symptoms than those who receive placebo plus standard benzodiazepine therapy.Subjects with
alcohol withdrawal syndrome(AWS)who receive baclofen plus standard benzodiazepine therapy
will experience fewer complications of AWS (as measured by use of additional sedatives,
restraints, and/or intensive care unit [ICU] admissions) compared with subjects who receive
placebo plus standard benzodiazepine therapy.
Oral Baclofen Pharmacokinetics and Pharmacodynamics in Children With Spasticity
Completed
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Phase 1/Phase 2
2008-11-01
Oral baclofen is used commonly to treat spasticity in children with cerebral palsy. Although
for adults there is dosing,safety and efficacy information in the package insert, this is not
the case for children. The purpose of this study is to determine how fast the drug is cleared
from the body, the correct dose, and long-term safety and efficacy for children with
spasticity.
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