CLINICAL TRIALS PROFILE FOR CORTAN

All Clinical Trials for CORTAN

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT01848067 ↗	Alisertib, Abiraterone Acetate and Prednisone in Treating Patients With Hormone-Resistant Prostate Cancer	Completed	Millennium: The Takeda Oncology Company	Phase 1/Phase 2	2013-08-14	This phase I/II trial studies the side effects and best dose of alisertib when given together with abiraterone acetate and prednisone and to see how well it works in treating patients with hormone-resistant prostate cancer. Alisertib and abiraterone acetate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Androgens can cause the growth of prostate cancer cells. Drugs, such as abiraterone acetate, may also lessen the amount of androgens made by the body. Drugs used in chemotherapy, such as prednisone, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving alisertib, abiraterone acetate, and prednisone together may be an effective treatment for prostate cancer.
NCT01848067 ↗	Alisertib, Abiraterone Acetate and Prednisone in Treating Patients With Hormone-Resistant Prostate Cancer	Completed	Sidney Kimmel Cancer Center at Thomas Jefferson University	Phase 1/Phase 2	2013-08-14	This phase I/II trial studies the side effects and best dose of alisertib when given together with abiraterone acetate and prednisone and to see how well it works in treating patients with hormone-resistant prostate cancer. Alisertib and abiraterone acetate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Androgens can cause the growth of prostate cancer cells. Drugs, such as abiraterone acetate, may also lessen the amount of androgens made by the body. Drugs used in chemotherapy, such as prednisone, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving alisertib, abiraterone acetate, and prednisone together may be an effective treatment for prostate cancer.
NCT02206425 ↗	Ixazomib as a Replacement for Carfilzomib and Bortezomib for Multiple Myeloma Patients	Active, not recruiting	Millennium: The Takeda Oncology Company	Phase 1/Phase 2	2014-09-01	The goal of this clinical research study is to evaluate the safety and effectiveness (good and bad effects) of ixazomib given as part of a combination therapy to treat subjects with relapsed (subjects whose disease came back) or refractory (subjects whose disease did not respond to past treatment) multiple myeloma. More specifically, the study is focused on subjects who were previously treated with bortezomib (Velcade®) or carfilzomib (Kyprolis®) and showed worsening of their myeloma while receiving either one of these drugs in combination therapy. This study is a Phase I/II. Ixazomib is an investigational drug, which means that ixazomib is currently being tested and is not yet approved by the United States Food and Drug Administration (FDA) for subjects with relapsed or refractory multiple myeloma. Ixazomib is a new study drug that belongs to the same class as bortezomib and carfilzomib; however, unlike bortezomib and carfilzomib, ixazomib is taken by mouth. Current studies investigating ixazomib are demonstrating that it is as safe as bortezomib and effective for the treatment of multiple myeloma both on its own and in combination with other multiple myeloma medications, such as lenalidomide and dexamethasone, or prednisone and melphalan.
NCT02206425 ↗	Ixazomib as a Replacement for Carfilzomib and Bortezomib for Multiple Myeloma Patients	Active, not recruiting	Takeda	Phase 1/Phase 2	2014-09-01	The goal of this clinical research study is to evaluate the safety and effectiveness (good and bad effects) of ixazomib given as part of a combination therapy to treat subjects with relapsed (subjects whose disease came back) or refractory (subjects whose disease did not respond to past treatment) multiple myeloma. More specifically, the study is focused on subjects who were previously treated with bortezomib (Velcade®) or carfilzomib (Kyprolis®) and showed worsening of their myeloma while receiving either one of these drugs in combination therapy. This study is a Phase I/II. Ixazomib is an investigational drug, which means that ixazomib is currently being tested and is not yet approved by the United States Food and Drug Administration (FDA) for subjects with relapsed or refractory multiple myeloma. Ixazomib is a new study drug that belongs to the same class as bortezomib and carfilzomib; however, unlike bortezomib and carfilzomib, ixazomib is taken by mouth. Current studies investigating ixazomib are demonstrating that it is as safe as bortezomib and effective for the treatment of multiple myeloma both on its own and in combination with other multiple myeloma medications, such as lenalidomide and dexamethasone, or prednisone and melphalan.

Clinical Trial Conditions for CORTAN

Condition Name

Condition Name for CORTAN
Intervention	Trials
Multiple Myeloma	2
Recurrent Prostate Cancer	1
Richter Syndrome	1
Stage IV Prostate Cancer	1

Condition MeSH

Condition MeSH for CORTAN
Intervention	Trials
Neoplasms, Plasma Cell	2
Multiple Myeloma	2
Aggression	1
Leukemia, Lymphocytic, Chronic, B-Cell	1

Clinical Trial Locations for CORTAN

Trials by Country

Trials by Country for CORTAN
Location	Trials
United States	19

Trials by US State

Trials by US State for CORTAN
Location	Trials
New York	3
Texas	2
Ohio	2
Florida	2
California	2

Clinical Trial Progress for CORTAN

Clinical Trial Phase

Clinical Trial Phase for CORTAN
Clinical Trial Phase	Trials
Phase 2	2
Phase 1/Phase 2	2
Phase 1	1

Clinical Trial Status

Clinical Trial Status for CORTAN
Clinical Trial Phase	Trials
Active, not recruiting	3
Completed	1
Not yet recruiting	1

Clinical Trial Sponsors for CORTAN

Sponsor Name

Sponsor Name for CORTAN
Sponsor	Trials
Genentech, Inc.	2
Weill Medical College of Cornell University	2
Millennium: The Takeda Oncology Company	2

Sponsor Type

Sponsor Type for CORTAN
Sponsor	Trials
Industry	9
Other	5