DrugPatentWatch Database Preview

RHOFADE Drug Profile

« Back to Dashboard

Which patents cover Rhofade, and when can generic versions of Rhofade launch?

Rhofade is a drug marketed by Aclaris and is included in one NDA. There are six patents protecting this drug.

This drug has twenty-one patent family members in twelve countries.

The generic ingredient in RHOFADE is oxymetazoline hydrochloride. There are three drug master file entries for this compound. Two suppliers are listed for this compound. Additional details are available on the oxymetazoline hydrochloride profile page.

Summary for RHOFADE

International Patents:	21
US Patents:	6
Applicants:	1
NDAs:	1
Suppliers / Packagers:	2
Bulk Api Vendors:	52
Clinical Trials:	1
Patent Applications:	1,017
Formulation / Manufacturing:	see details
Drug Prices:	Drug price information for RHOFADE
DailyMed Link:	RHOFADE at DailyMed

See drug prices for RHOFADE

Recent Clinical Trials for RHOFADE

Identify potential brand extensions & 505(b)(2) entrants

Sponsor	Phase
Actavis Inc.	Phase 3
Teva Pharmaceuticals USA	Phase 3

See all RHOFADE clinical trials

Pharmacology for RHOFADE

Drug Class	Vasoconstrictor
Physiological Effect	Vasoconstriction Increased Sympathetic Activity

Synonyms for RHOFADE

1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol hydrochloride

2-(3-Hydroxy-2,6-dimethyl-4-t-butylbenzyl)-2-imidazoline hydrochloride

2-(3-HYDROXY-2,6-DIMETHYL-4-TERT-BUTYLBENZYL)-2-IMIDAZOLINE HYDROCHLORIDE

2-(4-t-Butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazolinium chloride

2-(4-t-butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoliniumchloride

2-(4-tert-Butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazolinium chloride

2-(4-tert-butyl-3-hydroxy-2,6-dimethylbenzyl)-4,5-dihydro-1H-imidazol-1-ium chloride

2-[3-Hydroxy-2,6-dimethyl-4-t-butyl-benzyl]-2-imidazoline

2,6-Dimethyl-2-(4-tertiarybutyl-3-hydroxyphenyl)methylimidazoline hydrochloride

2,6-dimethyl-2-(4-tertiarybutyl-3-hydroxyphenyl)methylimidazolinehydrochlori

2,6-Dimethyl-4-tertiarybutyl-3-hydroxyphenyl)methylimidazoline hydrochloride

2315-02-8

3-[(4,5-Dihydro-

3-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethyl-phenol hydrochloride

315O028

4-Way Nasal Spray

6-(tert-butyl)-3-((4,5-dihydro-1H-imidazol-2-yl)methyl)-2,4-dimethylphenol hydrochloride

6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-phenohydrochloride

6-t-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol hydrochloride

6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenolhydrochloride

6-tert-butyl-3-((4,5-dihydro-1H-imidazol-2-yl)methyl)-2,4-dimethylphenol hydrochloride

6-tert-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol hydrochloride

6-tert-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol monohydrochloride

6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethyl-phenol hydrochloride

6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol hydrochloride

6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol;hydrochloride

AB2000600

AC1L24Z6

Afrazine

Afrin

Afrin hydrochloride

afrinhydrochloride

AKOS000280887

AN-10106

Anefrin nasal

BEEDODBODQVSIM-UHFFFAOYSA-N

Benzedrex Nasal Spray 12 Hour

CCG-40216

CHEBI:7863

CHEMBL1200791

CS-2533

CTK8G2231

D01022

Dristan Long Lasting Nasal Mist

DTXSID80177729

Duration 12 Hour Nasal Spray

Duration Nasal Spray

EINECS 219-015-0

EU-0100903

FT-0082561

HMS1568N09

HMS1920D18

HY-B0427A

iliadinhydrochloride

K89MJ0S5VY

KB-221830

KS-5222

LLiadin Mini Paediatric

Lliadine

LP00903

LS-104147

MCULE-1133105377

MFCD00017208

MFCD00058147

MLS000038040

MLS002222207

MolPort-000-709-375

Nafrine hydrochloride

Nasivin

Nasivine

NCGC00094218-01

NCGC00094218-02

NCGC00094218-03

NCGC00094218-04

NCGC00094218-05

NCGC00261588-01

Neo-Synephrine 12 Hour

Neo-Synephrine 12 Hour NTZ

Neonabel

Nostrilla

NSC-757254

NSC757254

O 2378

Ocuclear

Ocuclear (TN)

Opera_ID_32

Operil

Oximetazoline HCl

Oxymetazoline (hydrochloride)

Oxymetazoline chloride

Oxymetazoline HCl

Oxymetazoline hydrochloride

Oxymetazoline hydrochloride (JAN/USP)

Oxymetazoline hydrochloride [USAN:JAN]

Oxymetazoline hydrochloride [USAN:USP:JAN]

Oxymetazoline hydrochloride, >=99%, solid

Oxymetazoline hydrochloride, analytical standard

Oxymetazoline hydrochloride, European Pharmacopoeia (EP) Reference Standard

Oxymetazoline Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

Oxymetazoline hydrochloride, United States Pharmacopeia (USP) Reference Standard

Oxymetazoline Hydrochloride,(S)

Pharmakon1600-01500453

Phenol, 3-((4,5-dihydro-1H-imidazol-2-yl)methyl)-6-(1,1-dimethylethyl)-2,4-dimethyl-, monohydrochloride

Phenol, 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-, hydrochloride

Prestwick_373

Rhfade (TN)

Sch 9384

SCH-9384

SCHEMBL41247

Sinex

Sinex VapoSpray Moisturizing 12-Hour Decongestant UltraFine Mist

SMR000059324

SPECTRUM1500453

SR-01000002705

SR-01000002705-2

SR-01000002705-4

SR-01000002705-7

St. Joseph Nasal Spray for Children

Sudafed OM

SW196632-3

Tox21_500903

UNII-K89MJ0S5VY

V0297

Vicks Sinex

Visine L.R

Visine L.R.

W-107424

Paragraph IV (Patent) Challenges for RHOFADE

Tradename	Dosage	Ingredient	NDA	Submissiondate
RHOFADE	CREAM;TOPICAL	oxymetazoline hydrochloride	208552	2019-06-20

US Patents and Regulatory Information for RHOFADE

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
Aclaris	RHOFADE	oxymetazoline hydrochloride	CREAM;TOPICAL	208552-001	Jan 18, 2017		RX	Yes	Yes			Y
Aclaris	RHOFADE	oxymetazoline hydrochloride	CREAM;TOPICAL	208552-001	Jan 18, 2017		RX	Yes	Yes
Aclaris	RHOFADE	oxymetazoline hydrochloride	CREAM;TOPICAL	208552-001	Jan 18, 2017		RX	Yes	Yes

International Patents for RHOFADE

Country	Patent Number	Estimated Expiration
Portugal	2645993
Denmark	2645993
Mexico	2016016400