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MINOCIN Drug Profile

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When do Minocin patents expire, and what generic alternatives are available?

Minocin is a drug marketed by Bausch, Triax Pharms, Lederle, and Rempex Pharms. and is included in five NDAs. There are two patents protecting this drug.

This drug has thirty patent family members in twenty-two countries.

The generic ingredient in MINOCIN is minocycline hydrochloride. There are fifteen drug master file entries for this compound. Thirty-nine suppliers are listed for this compound. Additional details are available on the minocycline hydrochloride profile page.

US ANDA Litigation and Generic Entry Outlook for Minocin

A generic version of MINOCIN was approved as minocycline hydrochloride by WATSON LABS on December 30^th, 1991.

Summary for MINOCIN

International Patents:	30
US Patents:	2
Applicants:	4
NDAs:	5
Suppliers / Packagers:	4
Bulk Api Vendors:	115
Clinical Trials:	35
Patent Applications:	8,902
Formulation / Manufacturing:	see details
Drug Prices:	Drug price information for MINOCIN
DailyMed Link:	MINOCIN at DailyMed

See drug prices for MINOCIN

See drug sales revenues for MINOCIN

Recent Clinical Trials for MINOCIN

Identify potential brand extensions & 505(b)(2) entrants

Sponsor	Phase
Sun Yat-sen University	Phase 2
National Jewish Health	Phase 2
University of Texas Southwestern Medical Center	Phase 2

See all MINOCIN clinical trials

Pharmacology for MINOCIN

Drug Class

Tetracycline-class Drug

Synonyms for MINOCIN

(2E,4S,4aR,5aS,12aR)-2-(amino-hydroxy-methylidene)-4,7-bis(dimethylamino)-10,11,12a-trihydroxy-4a,5,5a,6-tetrahydro-4H-tetracene-1,3 ,12-trione

(4S-(4alpha,4aalpha,5aalpha,12aalpha))-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide monohydrochloride

(4S,12aS,4aS,5aR)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-4,5,6,12a,4a,5a-hexahydronaphthacene-2-carboxamide Hydrochloride

(4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-tetracenecarboxamide

(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE

(4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride

(4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide--hydrogen chloride (1/1)

(4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide

(minocycline)

[4S-(4?,4a?,5a?,12a?)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a,tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide

[4S-(4|A,4a|A,5a|A,12a|A)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide monohydrochloride

[4S-(4a,4aa,5aa,12aa)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a,tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide

[4S-(4alpha,4aalpha,5aalpha,12aalpha)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide monohydrochloride

0020414E5U

10118-90-8

10118-90-8 (base)

13614-98-7

1371-EP2269978A2

1371-EP2269985A2

1371-EP2269991A2

1371-EP2272832A1

1371-EP2284150A2

1371-EP2284151A2

1371-EP2284152A2

1371-EP2284153A2

1371-EP2284155A2

1371-EP2284156A2

1371-EP2284164A2

1371-EP2287140A2

1371-EP2287148A2

1371-EP2287150A2

1371-EP2289871A1

1371-EP2292590A2

1371-EP2292612A2

1371-EP2295402A2

1371-EP2295419A2

1371-EP2295426A1

1371-EP2295427A1

1371-EP2298732A1

1371-EP2301534A1

1371-EP2301912A2

1371-EP2301913A1

1371-EP2301914A1

1371-EP2301916A2

1371-EP2305637A2

1371-EP2308832A1

1371-EP2308863A1

1371-EP2311451A1

1371-EP2311796A1

1371-EP2311797A1

1371-EP2311798A1

1371-EP2311799A1

1371-EP2316450A1

18M908

2-Naphthacenecarboxamide, 4,7- bis(dimethylamino)-1,4,4a,5,5a,6,11,12a- octahydro-3,10,12,12a-tetrahydroxy-1,11dioxo-, monohydrochloride, [4S-(4alpha,4aalpha,5aalpha,12aalpha)]

2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S-(4alpha,4aalpha,5aalpha,12aalpha))-

2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)-

2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, monohydrochloride

2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, monohydrochloride, (4S-(4alpha,4aalpha,5aalpha,12aalpha))-

4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide

4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride

614M987

7-Dimethylamino-6-demethyl-6-deoxytetracycline

7-Dimethylamino-6-demethyl-6-deoxytetracycline, HCl

AB00053501_04

AB00053501_05

AB00053501-03

AB1009463

AC-22362

AC-30184

Acnez

AKOS015951312

AKOS015969674

AM20090714

API0003397

Arestin

Arestin (TN)

AS-75306

BCBcMAP01_000027

BCP06597

BCP9000928

BDBM50103599

Borymycin

BRN 3077644

BSPBio_002035

C07225

C23H27N3O7

C23H27N3O7.HCl

C23H28ClN3O7

CAS-10118-90-8

CAS-13614-98-7

CCG-40107

CHEBI:50694

CHEBI:50697

CHEMBL1200881

CHEMBL1434

CHEMBL259172

CL 59806

CS-1256

D00850

D05045

DB01017

DivK1c_000450

DSSTox_CID_24545

DSSTox_CID_25033

DSSTox_GSID_44545

DSSTox_GSID_45033

DSSTox_RID_80306

DSSTox_RID_80650

DTXSID1045033

DTXSID8044545

DYKFCLLONBREIL-KVUCHLLUSA-N

Dynacin

Dynacin (TN)

EINECS 237-099-7

FT-0082736

FT-0601821

FT-0628949

FXFM-244

FYY3R43WGO

GLMUAFMGXXHGLU-VQAITOIOSA-N

HMS1568P12

HMS2090D03

HSDB 3130

HY-17412

IDI1_000450

J-500789

J10198

KBio1_000450

KBio2_001447

KBio2_004015

KBio2_006583

KBio3_001535

KBioGR_000583

KBioSS_001447

KS-00000XT8

KSC-12-231B

KUC106429N

Lactoferrin B & Minocycline

Lactoferrin H & Minocycline

Lederderm

LMPK07000002

ls-007

LS-91518

LS-93850

LS-93852

M2288

MFCD00083669

MINO

Minociclina

Minociclina [INN-Spanish]

minociclinum

Minocin (Hydrochloride)

Minocin (TN)

Minocline

Minocyclin

minocycline

Minocycline (hydrochloride)

Minocycline (USAN/INN)

Minocycline [USAN:BAN:INN]

Minocycline [USAN:INN:BAN]

Minocycline chloride

Minocycline HCl

MINOCYCLINE HYDROCHLORIDE

Minocycline hydrochloride (internal use)

Minocycline hydrochloride (JP17/USP)

Minocycline hydrochloride [USAN:JAN]

Minocycline hydrochloride [USP:JAN]

Minocycline hydrochloride, 97%

Minocycline hydrochloride, Antibiotic for Culture Media Use Only

Minocycline hydrochloride, crystalline

Minocycline hydrochloride, European Pharmacopoeia (EP) Reference Standard

Minocycline Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

Minocycline hydrochloride, United States Pharmacopeia (USP) Reference Standard

Minocycline Monohydrochloride

minocycline-hcl

Minocycline, HCl

Minocycline, Hydrochloride

Minocyclinhydrochlorid

Minocyclinum

Minocyclinum [INN-Latin]

Minocyn

Minomax

Minomycin

Minomycin chloride

minomycin hydrochloride

Minoz

MIY

MLS002548863

Mynocine

Mynocine hydrochloride

NC00460

NCGC00096006-01

NCGC00178854-01

NCGC00178854-03

NCGC00183044-01

NCGC00188954-01

NCGC00255988-01

NINDS_000450

NSC-141993

NSC-757120

NSC141993

NSC757120

Periocline

Pharmakon1600-01500414

Prestwick_626

Prestwick0_000315

Prestwick1_000315

Prestwick2_000315

Q-201407

Q27104777

Q415336

S051

s4226

SBI-0051449.P003

SC-19210

SCHEMBL16681149

SCHEMBL24315

SCHEMBL2537

SCHEMBL4042

SMP1_000191

SMR001906766

Solodyn

Solodyn (TN)

SPBio_000974

SPBio_002529

Spectrum_000967

SPECTRUM1500414

Spectrum2_001047

Spectrum3_000508

Spectrum4_000062

Spectrum5_001293

SR-01000075625

SR-01000075625-1

SR-05000001675

SR-05000001675-3

ST24034766

Tox21_111250

Tox21_111250_1

Tox21_113183

Tox21_113643

Tox21_301590

Tri-mino

Tri-minocycline

UNII-0020414E5U

UNII-FYY3R43WGO

Vectrin

Vectrin (Hydrochloride)

W-5076

Ximino

ZINC100409820

ZINC14879992

ZINC4019704

US Patents and Regulatory Information for MINOCIN

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
Bausch	MINOCIN	minocycline hydrochloride	CAPSULE;ORAL	050649-001	May 31, 1990	AB	RX	Yes	No
Rempex Pharms	MINOCIN	minocycline hydrochloride	INJECTABLE;INJECTION	050444-001	Approved Prior to Jan 1, 1982		RX	Yes	Yes
Triax Pharms	MINOCIN	minocycline hydrochloride	CAPSULE;ORAL	050315-002	Approved Prior to Jan 1, 1982		DISCN	No	No
Rempex Pharms	MINOCIN	minocycline hydrochloride	INJECTABLE;INJECTION	050444-001	Approved Prior to Jan 1, 1982		RX	Yes	Yes
Bausch	MINOCIN	minocycline hydrochloride	CAPSULE;ORAL	050649-003	Feb 12, 2001		DISCN	Yes	No
Bausch	MINOCIN	minocycline hydrochloride	CAPSULE;ORAL	050649-002	May 31, 1990	AB	RX	Yes	No
Lederle	MINOCIN	minocycline hydrochloride	INJECTABLE;INJECTION	062139-001	Approved Prior to Jan 1, 1982		DISCN	No	No

International Patents for MINOCIN

Country	Patent Number	Estimated Expiration
Japan	6290298
World Intellectual Property Organization (WIPO)	2011143503
Chile	2012003168
Portugal	2568987
South Korea	101799304
Israel	222896
Australia	2011252919