DrugPatentWatch Database Preview
LONSURF Drug Profile
When do Lonsurf patents expire, and what generic alternatives are available?
Lonsurf is a drug marketed by Taiho Oncology and is included in one NDA. There are three patents protecting this drug.
This drug has sixty-nine patent family members in twenty-nine countries.
The generic ingredient in LONSURF is tipiracil hydrochloride; trifluridine. There are two drug master file entries for this compound. One supplier is listed for this compound. Additional details are available on the tipiracil hydrochloride; trifluridine profile page.
Summary for LONSURF
| International Patents: | 69 |
| US Patents: | 3 |
| Applicants: | 1 |
| NDAs: | 1 |
| Suppliers / Packagers: | 1 |
| Bulk Api Vendors: | 4 |
| Clinical Trials: | 18 |
| Formulation / Manufacturing: | see details |
| Drug Prices: | Drug price information for LONSURF |
| Prior Art and Litigation Support | Order Prior Art and Litigation support for LONSURF |
| DailyMed Link: | LONSURF at DailyMed |
Generic Entry Opportunity Date for LONSURF
Generic Entry Date for LONSURF*:
Constraining patent/regulatory exclusivity:
NDA:
Dosage:
TABLET;ORAL |
*The generic entry opportunity date is the latter of the last compound-claiming patent and the last regulatory exclusivity protection. Many factors can influence early or later generic entry. This date is provided as a rough estimate of generic entry potential and should not be used as an independent source.
Pharmacology for LONSURF
Synonyms for LONSURF
| 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione compound with 5-chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione (1:1) hydrochloride |
| AC-30108 |
| EX-A1755 |
| TAS 102 |
| Thymidine, alpha,alpha,alpha-trifluoro-, mixt. with 5-chloro-6-((2-imino-1-pyrrolidinyl)methyl)-2,4(1H,3H)-pyrimidinedione monohydrochloride |
| Tipiracil / Trifluridine |
| Tipiracil hydrochloride / Trifluridine |
| Tipiracil hydrochloride mixture with Trifluridine |
| Viroptic mixture with 5-CIMU |
US Patents and Regulatory Information for LONSURF
Expired US Patents for LONSURF
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | Patent No. | Patent Expiration |
|---|---|---|---|---|---|---|---|
| Taiho Oncology | LONSURF | tipiracil hydrochloride; trifluridine | TABLET;ORAL | 207981-001 | Sep 22, 2015 | ➤ Try a Free Trial | ➤ Try a Free Trial |
| Taiho Oncology | LONSURF | tipiracil hydrochloride; trifluridine | TABLET;ORAL | 207981-002 | Sep 22, 2015 | ➤ Try a Free Trial | ➤ Try a Free Trial |
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | Patent No. | Patent Expiration |
International Patents for LONSURF
| Country | Patent Number | Estimated Expiration |
|---|---|---|
| Taiwan | 201534601 | ➤ Try a Free Trial |
| European Patent Office | 3012255 | ➤ Try a Free Trial |
| Canada | 2914999 | ➤ Try a Free Trial |
| China | 1297350 | ➤ Try a Free Trial |
| Morocco | 38668 | ➤ Try a Free Trial |
| Cyprus | 1119393 | ➤ Try a Free Trial |
| Country | Patent Number | Estimated Expiration |
Supplementary Protection Certificates for LONSURF
| Patent Number | Supplementary Protection Certificate | SPC Country | SPC Expiration | SPC Description |
|---|---|---|---|---|
| 1849470 | LUC00036 | Luxembourg | ➤ Try a Free Trial | PRODUCT NAME: TRIFLURIDINE COMBINEE AU TIPIRACIL OU UN SEL DE TIPIRACIL TEL QUE L'HYDROCHLORURE DE TIPIRACIL; AUTHORISATION NUMBER AND DATE: EU/1/16/1096 20160427 |
| 1849470 | 300889 | Netherlands | ➤ Try a Free Trial | PRODUCT NAME: TRIFLURIDINE IN COMBINATIE MET TIPIRACILHYDROCHLORIDE; REGISTRATION NO/DATE: EU/1/16/1096 20160427 |
| 1849470 | 122017000052 | Germany | ➤ Try a Free Trial | PRODUCT NAME: TRIFLURIDIN IN KOMBINATION MIT TIPIRACIL ODER EINEM SALZ VON TIPIRACIL WIE TIPIRACIL-HYDROCHLORID; REGISTRATION NO/DATE: EU/1/16/1096 20160425 |
| 1849470 | 1790063-0 | Sweden | ➤ Try a Free Trial | PRODUCT NAME: TRIFLURIDINE IN COMBINATION WITH TIPIRACIL HYDROCHLORIDE; REG. NO/DATE: EU/1/16/1096 20160427 |
| 1849470 | 2017/033 | Ireland | ➤ Try a Free Trial | PRODUCT NAME: TRIFLURIDINE IN COMBINATION WITH TIPIRACIL HYDROCHLORIDE; REGISTRATION NO/DATE: EU/1/16/1096 20160425 |
| 1849470 | PA2017024 | Lithuania | ➤ Try a Free Trial | PRODUCT NAME: TRIFLURIDINAS/TIPIRACILAS; REGISTRATION NO/DATE: EU/1/16/1096 20160425 |
| Patent Number | Supplementary Protection Certificate | SPC Country | SPC Expiration | SPC Description |
