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Generated: April 21, 2019

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EVOMELA Drug Profile

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When do Evomela patents expire, and when can generic versions of Evomela launch?

Evomela is a drug marketed by Spectrum Pharms and is included in one NDA. There are four patents protecting this drug and one Paragraph IV challenge.

This drug has sixty patent family members in seventeen countries.

The generic ingredient in EVOMELA is melphalan hydrochloride. There are twelve drug master file entries for this compound. Nine suppliers are listed for this compound. Additional details are available on the melphalan hydrochloride profile page.

Drug patent expirations by year for EVOMELA
Pharmacology for EVOMELA
Drug ClassAlkylating Drug
Mechanism of ActionAlkylating Activity
Synonyms for EVOMELA
(2s)-2-amino-3-(4-[bis(2-chloroethyl)amino]phenyl)propanoic acid
(2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid
(2S)-2-amino-3-{4-[bis(2-chloroethyl)amino]phenyl}propanoic acid
(2S)-2-azanyl-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid
(S)-2-amino-3-(4-(bis(2-chloroethyl)amino)phenyl)propanoic acid
(S)-2-Amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid
148-82-3
148M823
2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]-propanoic acid
2-amino-3-[4-bis(2-chloroethyl)amino]phenylpropanoic acid
2-Amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid
2-Amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid (Melphalan)
2-Amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid(L-PAM)
2-Amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid(Melphalan)
3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine
3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine
3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanine
3025 c.b
3025 C.B.
4-(Bis(2-chloroethyl)amino)-L-phenylalanine
4-(Bis(2-chloroethyl)amino)phenylalanine
4-[Bis-(2-chloroethyl)amino]-L-phenylalanine
4-[bis(2-chloroethyl)-amino]-l-phenyl-alanine
4-[bis(2-chloroethyl)-amino]-L-phenylalanine
4-[bis(2-chloroethyl)amino]-(L)-phenylalanine
4-[Bis(2-chloroethyl)amino]-L-phenylalanine
4-[Bis(2-chloroethyl)amino]phenylalanine
4-14-00-01689 (Beilstein Handbook Reference)
8057-25-8
A808810
AB0005221
AB00053282_09
AB00053282-07
AB00053282-08
AB2000419
AC1LA2OE
AKOS015895374
Alanine Nitrogen Mustard
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, L-
Alanine, 3-[p-[bis(2-chloroethyl)amino]phenyl]-, L-
Alkeran
ALKERAN (TN)
Alkeran;L-Phenylalanine mustard;L-PAM
AN-976
API0003288
AS-13314
AY33600000
BDBM50025837
BIDD:GT0044
BRD-K87827419-001-02-8
BRN 2816456
BSPBio_002407
C-19011
C07122
CAS-148-82-3
CB 3025
CB-3025
CC-30199
CCG-39704
CCRIS 374
CHEBI:28876
CHEMBL852
CS-3120
CTK5E7915
D00369
DB01042
DivK1c_000653
DL-442
DL-Melphalan hydrochloride
DSSTox_CID_804
DSSTox_GSID_20804
DSSTox_RID_75797
DTXSID6020804
EINECS 205-726-3
Epitope ID:141802
FT-0603357
GTPL7620
H877
HMS2090B09
HMS2091B16
HMS2235D21
HMS502A15
HSDB 3234
HY-17575
IDI1_000653
K-4728
KBio1_000653
KBio2_000877
KBio2_003445
KBio2_006013
KBio3_001627
KBioGR_001284
KBioSS_000877
KS-00001D9Q
L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine
L-3-(para-(Bis(2-chloroethyl)amino)phenyl)alanine
L-PAM
L-Phenylalanine mustard
L-phenylalanine mustard (L-PAM)
L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-
L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-
L-Sarcolysin
L-Sarcolysine
L-Sarkolysin
Levofalan
Levofolan
Levopholan
LS-15868
LS-865
Melfalan
Melfalano
Melfalano [INN-Spanish]
melphalan
Melphalan (JP17/USP/INN)
MELPHALAN (SEE ALSO TRANSGENIC MODEL EVALUATION (MELPHALAN))
Melphalan [USAN:INN:BAN:JAN]
Melphalan [USAN:USP:INN:BAN:JAN]
Melphalan-d8 Dihydrochloride
Melphalan, 94%
Melphalan, powder
Melphalanum
Melphalanum [INN-Latin]
MLS001333666
MLS002153368
MolPort-003-665-535
NCGC00090757-01
NCGC00090757-02
NCGC00090757-03
NCGC00090757-04
NCGC00090757-05
NCGC00090757-06
NCGC00260071-01
NCI-C04853
NINDS_000653
NIOSH/AY3360000
NSC 241286
NSC 8806
NSC-757098
NSC-8806
NSC241286
NSC757098
NSC8806
p-Bis(beta-chloroethyl)aminophenylalanine
p-Di-(2-chloroethyl)amino-L-phenylalanine
p-L-Sarcolysin
p-L-sarcolysine
p-N-Bis(2-chloroethyl)amino-L-phenylalanine
p-N-di(chloroethyl)aminophenylala nine
p-N-Di(chloroethyl)aminophenylalanine
p-N,N-bis(2-chloroethyl)amino-L-phenylalanine
Pharmakon1600-01500382
Phenylalanine mustard
phenylalanine nitrogen mu stard
Phenylalanine nitrogen mustard
Phenylalanine, 4-[bis(2-chloroethyl)amino]-
Prestwick_1006
Q41OR9510P
RCRA waste no. U150
Rcra waste number U150
s8266
Sarcolysinum
SBI-0052787.P003
SCHEMBL5872
SGDBTWWWUNNDEQ-LBPRGKRZSA-N
SK-15673
SMP2_000174
SMR000058720
SPBio_000287
Spectrum_000397
SPECTRUM1500382
Spectrum2_000074
Spectrum3_000684
Spectrum4_000882
Spectrum5_001601
SR-05000001667
SR-05000001667-1
TL8001065
Tox21_111010
Tox21_111010_1
Tox21_202522
TRANSGENIC LEP (MELPHALAN) (SEE ALSO MELPHALAN)
TRANSGENIC MODEL EVALUATION (MELPHALAN)
UNII-A960M0G5TP component SGDBTWWWUNNDEQ-LBPRGKRZSA-N
UNII-Q41OR9510P
W-108096
ZINC1673

US Patents and Regulatory Information for EVOMELA

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Spectrum Pharms EVOMELA melphalan hydrochloride POWDER;INTRAVENOUS 207155-001 Mar 10, 2016 RX Yes Yes ➤ Try a Free Trial ➤ Try a Free Trial Y ➤ Try a Free Trial
Spectrum Pharms EVOMELA melphalan hydrochloride POWDER;INTRAVENOUS 207155-001 Mar 10, 2016 RX Yes Yes ➤ Try a Free Trial ➤ Try a Free Trial Y ➤ Try a Free Trial
Spectrum Pharms EVOMELA melphalan hydrochloride POWDER;INTRAVENOUS 207155-001 Mar 10, 2016 RX Yes Yes ➤ Try a Free Trial ➤ Try a Free Trial Y ➤ Try a Free Trial
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration

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Paragraph IV (Patent) Challenges for EVOMELA
Drugname Dosage Strength RLD Date
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