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CYCLOPHOSPHAMIDE Drug Profile

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Which patents cover Cyclophosphamide, and when can generic versions of Cyclophosphamide launch?

Cyclophosphamide is a drug marketed by Amerigen Pharms Ltd, Sti Pharma Llc, West-ward Pharms Int, Amneal Pharms Co, Baxter Hlthcare, Jiangsu Hengrui Med, and Roxane. and is included in eleven NDAs.

The generic ingredient in CYCLOPHOSPHAMIDE is cyclophosphamide. There are nineteen drug master file entries for this compound. Six suppliers are listed for this compound. Additional details are available on the cyclophosphamide profile page.

Summary for CYCLOPHOSPHAMIDE

US Patents:	0
Applicants:	7
NDAs:	11
Suppliers / Packagers:	6
Bulk Api Vendors:	60
Clinical Trials:	2,633
Patent Applications:	4,387
Formulation / Manufacturing:	see details
Drug Prices:	Drug price information for CYCLOPHOSPHAMIDE
DailyMed Link:	CYCLOPHOSPHAMIDE at DailyMed

Pharmacology for CYCLOPHOSPHAMIDE

Drug Class	Alkylating Drug
Mechanism of Action	Alkylating Activity

Medical Subject Heading (MeSH) Categories for CYCLOPHOSPHAMIDE

Antineoplastic Agents, Alkylating

Antirheumatic Agents

Immunosuppressive Agents

Mutagens

Myeloablative Agonists

Synonyms for CYCLOPHOSPHAMIDE

(-)-Cyclophosphamide

(.+/-.)-Cyclophosphamide

(+-)-Cyclophosphamide

(+-)-N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

(+/-)-2-[Bis(2-chloroethyl)amino]tetrahydro-2 H-1,3,2-oxazaphosphorine 2-oxide

(Bis(chloro-2-ethyl)amino)-2-tetrahydro-3,5,6-oxazaphosphorine-1,3,2-oxide-2 hydrate

(R)-2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin 2-oxide

(RS)-Cyclophosphamide

(S)-2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide

[Bis(chloro-2-ethyl)amino]-2-tetrahydro-3,5,6-oxazaphosphorine-1,3,2-oxide-2 hydrate

005C978

1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine

1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin

110841-EP2272827A1

110841-EP2298305A1

139301-EP2270008A1

139301-EP2292617A1

173547-45-0

2-(bis(2-Chloroethyl)-amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide

2-(bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide

2-(Bis(2-chloroethyl)amino)-2H-1,2-oxazaphosphorine 2-oxide

2-(Bis(2-chloroethyl)amino)-2H-1,3,2-oxazaphosphorine 2-oxide

2-(Bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazophosphorine 2-oxide

2-(di(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphacyclohexane 2-oxide

2-(Di(2-chloroethyl)amino)-2-phospha(V)-tetrahydro-2H-1,3-oxazine-2-one

2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphosphaperhydroin-2-one

2-[bis(2-chloroethyl)amino]-1,3,2$l;{5}-oxazaphosphinan-2-one

2-[Bis(2-chloroethyl)amino]-2H-1,2-oxazaphosphorine 2-oxide

2-[Bis(2-chloroethyl)amino]tetrahydro-1,3,2-oxazaphosphorin-2-oxide

2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXA

2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide

2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide

27353-EP2269998A2

27353-EP2272516A2

27353-EP2275404A1

27353-EP2275469A1

27353-EP2284171A1

27353-EP2287940A1

27353-EP2292227A2

27353-EP2295550A2

27353-EP2298762A2

27353-EP2298768A1

27353-EP2308839A1

27353-EP2314587A1

27353-EP2371795A1

2H-1,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide

2H-1,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide, (-)-

2H-1,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide, (+)-

2H-1,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide

2H-1,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate

2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide

2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide (9CI)

2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide, (+-)-

2H-1,3,2-Oxazaphosphorine, 2-(bis(2-chloroethyl)amino)tetrahydro-, 2-oxide

2H-1,3,2-Oxazaphosphorine, 2-(bis(2-chloroethyl)amino)tetrahydro-,2-oxide

3356-EP2269989A1

3356-EP2270001A1

3356-EP2270008A1

3356-EP2270014A1

3356-EP2270018A1

3356-EP2270505A1

3356-EP2272822A1

3356-EP2272825A2

3356-EP2272827A1

3356-EP2275102A1

3356-EP2275412A1

3356-EP2275413A1

3356-EP2275420A1

3356-EP2277865A1

3356-EP2277876A1

3356-EP2280012A2

3356-EP2281815A1

3356-EP2281818A1

3356-EP2287156A1

3356-EP2289892A1

3356-EP2289894A2

3356-EP2292233A2

3356-EP2292595A1

3356-EP2292614A1

3356-EP2292615A1

3356-EP2292617A1

3356-EP2295055A2

3356-EP2295412A1

3356-EP2295413A1

3356-EP2295416A2

3356-EP2295426A1

3356-EP2295427A1

3356-EP2298743A1

3356-EP2298746A1

3356-EP2298748A2

3356-EP2298764A1

3356-EP2298765A1

3356-EP2298767A1

3356-EP2298768A1

3356-EP2298772A1

3356-EP2298778A1

3356-EP2298780A1

3356-EP2301928A1

3356-EP2301933A1

3356-EP2305250A1

3356-EP2305640A2

3356-EP2305642A2

3356-EP2305671A1

3356-EP2305677A1

3356-EP2305689A1

3356-EP2308812A2

3356-EP2308833A2

3356-EP2308839A1

3356-EP2308855A1

3356-EP2308861A1

3356-EP2311453A1

3356-EP2311807A1

3356-EP2311808A1

3356-EP2311825A1

3356-EP2311827A1

3356-EP2311829A1

3356-EP2311837A1

3356-EP2311840A1

3356-EP2311842A2

3356-EP2314587A1

3356-EP2314590A1

3356-EP2316831A1

3356-EP2316832A1

3356-EP2316833A1

3356-EP2316834A1

3356-EP2371811A2

3356-EP2374454A1

4-Hydroxy-cyclophosphan-mamophosphatide

50-18-0

60007-95-6

60007-96-7

6055-19-2 (monohydrate)

75526-90-8

AB00053446_13

AB00053446_14

AB00053446_15

AB00053446-09

AB00053446-11

AB00053446-12

AB0007927

ABP000629

AC1L1EQQ

ACM173547450

AI3-26198

AK322029

AKOS005410738

AN-6966

Anhydrous cyclophosphamide

API0002151

ARONIS24566

ASTA

Asta B 518

ASTA B518

B 518

B-518

BBC/739

BBL022697

BC200624

bis(2-Chloroethyl)phosphami de cyclic propanolamide

bis(2-Chloroethyl)phosphamide cyclic propanolamide ester

Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester

BRN 0011744

BSPBio_002099

C 0768

C07888

CB 4564

CB-4564

CCRIS 188

CHEBI:4027

CHEMBL88

Ciclofosfamida

Ciclofosfamida [INN-Spanish]

Ciclofosfamide

Ciclophosphamide

Ciclophosphamide [INN]

Clafen

Clafen(Cyclophosphamide)

Clafen(Cyclophosphamide)/

Claphene

CMSMOCZEIVJLDB-UHFFFAOYSA-

CMSMOCZEIVJLDB-UHFFFAOYSA-N

CS-1425

CTK2F5582

CY

Cycloblastin

Cyclofosphamide

CYCLOPHOSPAMIDE MONOHYDRATE

Cyclophosphamid

Cyclophosphamide (anhydrous form)

Cyclophosphamide (anhydrous)

Cyclophosphamide (INN)

Cyclophosphamide (TN)

Cyclophosphamide [USP]

Cyclophosphamide anhydrous

Cyclophosphamide Sterile

Cyclophosphamide-d4

Cyclophosphamide, (+-)-Isomer

Cyclophosphamides

Cyclophosphamidum

Cyclophosphamidum [INN-Latin]

Cyclophosphan

Cyclophosphane

Cyclophosphanum

Cyclophosphoramide

Cyclostin

Cyklofosfamid

Cyklofosfamid [Czech]

Cytophosphan

Cytophosphane

Cytoxan

Cytoxan (TN)

Cytoxan Lyoph

D,L-Cyclophosphamide

D07760

D0CT9C

DB00531

DivK1c_000246

DTXSID5020364

EINECS 200-015-4

EN300-74526

Endoxan

Endoxan (TN)

Endoxan R

Endoxan-Asta

Endoxana

Endoxanal

Endoxane

Enduxan

Epitope ID:131782

EU-0100238

FT-0624276

Genoxal

GTPL7154

HE021286

HE186689

HE186690

HE318321

HE345965

HMS2090A12

HMS3260P17

HSDB 3047

HY-17420

IDI1_000246

InChI=1/C7H15Cl2N2O2P/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14/h1-7H2,(H,10,12)

KBio1_000246

KBio2_001338

KBio2_003906

KBio2_006474

KBio3_001319

KBioGR_000888

KBioSS_001338

KS-00000XHN

Ledoxina

Lopac-C-0768

Lopac0_000238

LP00238

LS-1302

LS-99787

Lyophilized Cytoxan

Lyophilizedcytoxan

MCULE-5327530727

MFCD00005978

Mitoxan

MolPort-001-783-420

N-bis(beta-Chloroethyl)-N'O,trimethylenephos phoric acid ester diamide

N-bis(beta-Chloroethyl)-N'O,trimethylenephosphoric acid ester diamide

N,3,2-oxazaphosphorin-2-amine-2-oxide

N,N-Bis-(.beta.-chloraethyl)-N',O-propylen-phosphorsaeure-ester-diamid

N,N-Bis-(beta-chloraethyl)-N',O-propylen-phosphorsaeure-ester-diamid

N,N-Bis-(beta-chloraethyl)-N',O-propylen-phosphorsaeure-ester-diamid [German]

N,N-Bis(.beta.-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide

N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide

N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide (H2O)

N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide #

N,N-bis(2-chloroethyl)-2-oxo-1-oxa-3-aza-2$l^{5}-phosphacyclohexan-2-amine

N,N-bis(2-chloroethyl)-2-oxo-1,3,2$l^{5}-oxazaphosphinan-2-amine

N,N-bis(2-chloroethyl)-N'-(3-h ydroxypropyl)phosphorodiamidic acid intramol. ester

N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)phosphorodiamidic acid intramol. ester

N,N-Bis(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide

N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine-2-oxide

N,N-Bis(2-Chloroethyl)tetrahydro-2H-1,3,2-Oxazaphosphorin-2-Amine, 2-Oxide

N,N-Bis(beta-chloroethyl)-N',O-propylenephosphoric acid ester diamide

N,N-Bis(beta-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide

N,N-Di(2-chloroethyl)-N,O-propylene-phosphoric acid ester diamide

N,O-propylen-phosphorsaeure-ester-diamid

N,O-propylene-phosphoric acid ester diamide

N,O-propylenephosphoric acid ester amide monohydrate

N,O-propylenephosphoric acid ester diamide

N,O-trimethylenephosphoric acid ester diamide

NCGC00015209-01

NCGC00015209-02

NCGC00015209-03

NCGC00015209-04

NCGC00015209-05

NCGC00015209-06

NCGC00015209-07

NCGC00015209-08

NCGC00015209-09

NCGC00015209-12

NCGC00091741-02

NCGC00091741-03

NCGC00260923-01

NCI-C04900

NCI60_002097

Neosar

Neosar (TN)

NINDS_000246

NSC 26271

NSC-26271

NSC-273033

NSC-273034

NSC-756711

NSC26271

NSC273033

NSC273034

NSC756711

Occupation, cyclophosphamide exposure

Pharmakon1600-01500213

Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)-, intramol. ester

Phosphorodiamidic acid,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)-, intramol. ester

Procytox

Procytox (TN)

RCRA waste no. U058

Rcra waste number U058

Revimmune

Revimmune (TN)

SBI-0050226.P003

SC-22408

SC-47258

SC-91286

SCHEMBL10262910

SCHEMBL4345553

SCHEMBL4346

Semdoxan

Sendoxan

Senduxan

SK 20501

SPBio_001071

Spectrum_000858

Spectrum2_001146

Spectrum3_000370

Spectrum4_000304

Spectrum5_000795

SR-01000075737

SR-01000075737-1

ST51005945

STK177249

STOCK2S-91217

tatrahydro-2-(Bis(2-chloroethyl)amino)-2H-1,3,2-oxazaphosphorine 2-oxide

TC-063558

te trahydro-N,N-bis(2-chloroethyl)-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

tetrahydro-N,N-bis(2-chloroethyl)-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

Tox21_500238

TR-037249

UNII-6UXW23996M component CMSMOCZEIVJLDB-CQSZACIVSA-N

W-105248

W-5035

W-60377

WLN: T6MPOTJ BO BN2G2G

ZX-AS004939

Zyklophosphamid

Zyklophosphamid [German]

US Patents and Regulatory Information for CYCLOPHOSPHAMIDE

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
Amerigen Pharms Ltd	CYCLOPHOSPHAMIDE	cyclophosphamide	CAPSULE;ORAL	207014-001	Mar 19, 2018	AB	RX	No	No
Jiangsu Hengrui Med	CYCLOPHOSPHAMIDE	cyclophosphamide	INJECTABLE;INJECTION	204555-003	Oct 31, 2014	AP	RX	No	No
Amneal Pharms Co	CYCLOPHOSPHAMIDE	cyclophosphamide	INJECTABLE;INJECTION	210046-002	May 25, 2018	AP	RX	No	No
Sti Pharma Llc	CYCLOPHOSPHAMIDE	cyclophosphamide	CAPSULE;ORAL	209872-002	May 7, 2018	AB	RX	No	No
Baxter Hlthcare	CYCLOPHOSPHAMIDE	cyclophosphamide	INJECTABLE;INJECTION	040745-003	May 21, 2008	AP	RX	No	Yes