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Generated: April 24, 2018

DrugPatentWatch Database Preview

BLOCADREN Drug Profile

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When do Blocadren patents expire, and what generic alternatives are available?

Blocadren is a drug marketed by Merck and is included in one NDA.

The generic ingredient in BLOCADREN is timolol maleate. There are fifteen drug master file entries for this compound. Sixteen suppliers are listed for this compound. Additional details are available on the timolol maleate profile page.
Drug patent expirations by year for BLOCADREN
Synonyms for BLOCADREN
(-)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)-2-propanol maleate
(-)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)-2-propanol maleate (1:1) (salt)
(-)-3-Morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazole
(-)-Timolol
(2S)-1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol
(2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
(2S)-1-(tert-butylamino)-3-{[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy}propan-2-ol
(2S)-1-(tert-butylamino)-3-{[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy}propan-2-ol (2Z)-but-2-enedioate
(2S)-1-(TERT-BUTYLAMINO)-3-{[4-(MORPHOLIN-4-YL)-1,2,5-THIADIAZOL-3-YL]OXY}PROPAN-2-OL; MALEIC ACID
(2S)-1-[(1,1-dimethylethyl)amino]-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
(2S)-1-[(1,1-Dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol (2Z)-2-Butenedioate Salt
(2S)-3-[(tert-butyl)amino]-1-(4-morpholin-4-yl(1,2,5-thiadiazol-3-yl)oxy)propa n-2-ol
(2Z)-but-2-enedioic acid; tert-butyl[(2S)-2-hydroxy-3-{[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy}propyl]amine
(S)-(-)-3-Morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazole Hydrogen Maleate
(S)-(-)-Timolol Maleate
(S)-1-(1,1-(Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol
(S)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol
(S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
(S)-1-[(1,1-Dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol maleate
(S)-1-tert-Butylamino-3-(4-morpholin-4-yl-[1,2,5]thiadiazol-3-yloxy)-propan-2-ol
(S)-3-(3-(tert-bUtylamino)-2-hydroxypropoxy)-4-morpholino-1,2,5-thiadiazole maleate
(S)-3-(3-(tert-Butylamino)-2-hydroxypropoxy)-4-morpholino-1,2,5-thiadiazole monomaleate
(S)-timolol
(S)-timolol (anhydrous)
(S)-Timolol (Maleate)
(S)-Timolol hydrogen maleate
(S)-Timolol maleate
(Z)-but-2-enedioic acid; (2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
(Z)-but-2-enedioic acid;(2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
1-( tert-Butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol maleate
1-(tert-butylamino)-3-[4-(1,4-oxazinan-4-yl)-1,2,5-thiadiazol-3-yloxy]-(2S)-propan-2-ol
131628-37-0
194288-09-0
2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, (2S)-
2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, (S)-
2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, (S)-, (Z)-2-butenedioate (1:1) (salt)
2-Propanol, 1-(tert-butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)-, (-)-, maleate (1:1) (salt)
2-Propanol, 1-(tert-butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)-, (-)-,maleate (1:1) (salt)
2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-, (2S)-
2-Propanol,1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-,(2S)-
26839-75-8
26839-75-8 (Parent)
26921-17-5
26921-17-5 (maleate (1:1) salt)
30166-36-0
3B1-003748
5JKY92S7BR
60469-65-0
839T758
921T175
AB0021275
AB00513729
AB00513729-17
AC1L1PYN
AC1NQXYE
AC1Q59QM
AKOS015969764
AKOS024458595
API0004422
Apo-Timol
Apo-Timol (TN)
Apo-Timop
Apo-Timop (TN)
Aquanil
ARONIS24479
arutimol
AS-18090
BBC/645
BDBM50292219
Betim
Betime
Betimol
Betimol (TN)
BG0340
BIDD:GT0073
Bimatoprost / timolol
Bio-0875
BLJRIMJGRPQVNF-JTQLQIEISA-N
Blocadren (TN)
BPBio1_001008
BRD-K08806317-050-03-6
BSPBio_000916
C-19486
C07141
C13H24N4O3S.C4H4O4
CAS-26839-75-8
CAS-26921-17-5
CC-35068
CCG-220948
CCRIS 1057
CHEBI:9599
CHEBI:9600
CHEMBL1200870
CHEMBL499
CPD000653470
CS-1028
CTK4F8602
D00603
D05UVD
D08600
DB00373
DSSTox_CID_27504
DSSTox_CID_3674
DSSTox_GSID_23674
DSSTox_GSID_47504
DSSTox_RID_77140
DSSTox_RID_82384
DTXSID3047504
DTXSID4023674
EINECS 248-032-6
EINECS 248-111-5
EINECS 262-251-4
FT-0082529
FT-0630529
Gen-Timolol (TN)
GTPL565
HE061310
HE068325
HE330337
HMS1570N18
HMS2089I11
HMS2097N18
HMS2230N19
HMS2234F03
HMS3259C20
HSDB 6533
HY-17380
Istalol
Istalol (TN)
KB-61736
L-714,465
L-Timolol
l-Timolol maleate
Lopac-T-6394
Lopac0_001189
LS-121851
LS-122231
MFCD00058356
MK 950
MK-950
MLS000028539
MLS001076135
MolPort-002-545-241
MolPort-006-125-123
NC00592
NCGC00016038-01
NCGC00016038-02
NCGC00016798-01
NCGC00016798-02
NCGC00016798-03
NCGC00016798-05
NCGC00016798-06
NCGC00016798-07
NCGC00016798-08
NCGC00016798-09
NCGC00016798-11
NCGC00022033-02
NCGC00022033-04
NCGC00022033-05
NCGC00256737-01
Novo-Timol
Nu-Timolol
Nu-Timolol (TN)
Opera_ID_1256
Oprea1_640981
Optimol
P8Y54F701R
Phoxal-timolol
Phoxal-timolol (TN)
PMS-Timolol (TN)
Prestwick0_000948
Prestwick1_000948
Prestwick2_000948
Prestwick3_000948
Proflax
Q-201836
S-(-)-1-(t-Butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol maleate salt
S-(-)-3-(3-tert-Butylamino-2-hydroxypropoxy)-4-morpholino-1,2,5-thiadiazole
S(-)-Timolol maleate
s4123
SAM002564238
SCHEMBL26233
SCHEMBL4912
SMR000058305
SMR000653470
SPBio_003075
ST072193
Temserin
Tenopt
TIM
Tim-AK
Tim-AK (TN)
Timacar
Timacor
timolol
Timolol (INN)
Timolol (TN)
Timolol [USAN:INN]
Timolol [USAN]
Timolol anhydrous
Timolol for system suitability, European Pharmacopoeia (EP) Reference Standard
Timolol GFS
Timolol hydrogen maleate
Timolol hydrogenmaleate
Timolol maleate
Timolol maleate (JP17/USP)
Timolol maleate [USAN:JAN]
Timolol maleate [USAN:USP:JAN]
Timolol Maleate 1.0 mg/ml in Methanol (as free base)
Timolol maleate salt
Timolol maleate salt, >=98% (TLC), powder
Timolol Maleate, (1:1) Salt
Timolol maleate, British Pharmacopoeia (BP) Reference Standard
Timolol maleate, European Pharmacopoeia (EP) Reference Standard
Timolol maleate, United States Pharmacopeia (USP) Reference Standard
Timololo
Timololum
Timololum [INN-Latin]
Timopic
Timoptic
Timoptic (TN)
Timoptic in Ocudose
Timoptic OcuDose
Timoptic OcuDose. (TN)
Timoptic-XE
Timoptic-XE (TN)
Timoptic?XE
Timoptol
Tocris-0649
Tox21_110614
Tox21_110614_1
Tox21_302468
UNII-5JKY92S7BR
UNII-P8Y54F701R
W-107148
W0079
WLRMANUAADYWEA-NWASOUNVSA-N
ZINC2176

US Patents and Regulatory Information for BLOCADREN

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Merck BLOCADREN timolol maleate TABLET;ORAL 018017-001 Approved Prior to Jan 1, 1982 DISCN No No ➤ Sign Up ➤ Sign Up ➤ Sign Up
Merck BLOCADREN timolol maleate TABLET;ORAL 018017-002 Approved Prior to Jan 1, 1982 DISCN No No ➤ Sign Up ➤ Sign Up ➤ Sign Up
Merck BLOCADREN timolol maleate TABLET;ORAL 018017-004 Approved Prior to Jan 1, 1982 DISCN No No ➤ Sign Up ➤ Sign Up ➤ Sign Up
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration

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Expired US Patents for BLOCADREN

Applicant Tradename Generic Name Dosage NDA Approval Date Patent No. Patent Expiration
Merck BLOCADREN timolol maleate TABLET;ORAL 018017-004 Approved Prior to Jan 1, 1982 ➤ Sign Up ➤ Sign Up
Merck BLOCADREN timolol maleate TABLET;ORAL 018017-001 Approved Prior to Jan 1, 1982 ➤ Sign Up ➤ Sign Up
Merck BLOCADREN timolol maleate TABLET;ORAL 018017-002 Approved Prior to Jan 1, 1982 ➤ Sign Up ➤ Sign Up
Applicant Tradename Generic Name Dosage NDA Approval Date Patent No. Patent Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Fish and Richardson
Citi
Argus Health
Deloitte
Boehringer Ingelheim
Colorcon
UBS
Chubb
Healthtrust

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