Last updated: August 5, 2025
Introduction
Metronidazole remains a cornerstone in antimicrobial therapy, predominantly used to treat protozoal infections and anaerobic bacterial infections. Its commercial viability hinges on reliable sourcing, quality, and container compatibility. The demand for metronidazole in plastic containers has surged due to ease of storage, portability, and reduced risk of container breakage. For pharmaceutical companies, identifying credible suppliers offering high-quality metronidazole in suitable plastic packaging is critical to maintaining supply chain integrity and regulatory compliance.
Market Overview of Metronidazole Suppliers
The global pharmaceutical landscape has expanded to feature numerous manufacturers and suppliers specializing in metronidazole. Key players include multinational corporations with proven track records in active pharmaceutical ingredient (API) production and reputable contract manufacturing organizations (CMOs). The focus now shifts to those offering not just API but packaged products in plastic containers, aligning with current sterile and non-sterile formulation demands.
Leading Suppliers of Metronidazole in Plastic Containers
1. Premier Pharmaceutical Manufacturers
Some of the large-scale API producers also provide finished formulations ready for distribution in plastic containers:
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Zhejiang Huahai Pharmaceutical Co., Ltd. – Based in China, this company produces high-grade metronidazole API and offers finished products packaged in various container types, including plastics, complying with Good Manufacturing Practices (GMP). Their capacity and international certifications position them as a reliable supplier.
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Zydus Cadila Healthcare Ltd. – An Indian pharmaceutical giant with robust API manufacturing capabilities, Zydus supplies metronidazole in bulk, with options for final formulation in plastic bottles tailored for oral administration.
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Hubei Bestdrug Biotechnology Co., Ltd. – Specializing in antimicrobial APIs, this Chinese manufacturer supplies metronidazole in various formulations and packaging solutions, including plastic containers suitable for domestic and export markets.
2. Contract Manufacturing and Packaging Specialists
Contract manufacturers have emerged as vital partners, especially for companies seeking turnkey solutions:
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Capsugel (Now Lonza Capsule & finished dosage form division) – Though primarily known for capsule manufacturing, Lonza offers advanced packaging solutions, including plastic containers designed for oral antibiotics such as metronidazole, ensuring cGMP compliance.
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Famar – A European-based CMO providing contract production, packaging, and distribution services for oral solid and liquid drugs, including metronidazole in plastic bottles with tamper-evident features.
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Neolab Pharmaceuticals – An Indian CMO specializing in oral liquids and tablets, offering custom packaging options such as polyethylene bottles conforming to pharmaceutical standards.
3. Regional Suppliers & Distributors
Regional suppliers cater to local markets and often provide competitive pricing and faster delivery:
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Mixtures & Assured Supplies India Pvt. Ltd. – Offers metronidazole APIs and finished products in plastic bottles for domestic and nearby markets.
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Sino Biopharmaceutical Limited – With a focus on antimicrobial agents, they supply metronidazole in various packaging formats, including plastics.
Key Considerations When Selecting Suppliers
- Regulatory Compliance: Suppliers must comply with GMP and have certifications such as FDA, EMA, or WHO-GMP to ensure product quality.
- Quality Assurance: Stringent quality controls for API purity, stability, and container compatibility.
- Container Compatibility: Plastic containers should be made of materials like HDPE or PET, suited for oral medications, with features like child resistance or tamper evidence.
- Supply Chain Reliability: Consistent capacity, lead times, and proven logistical capabilities.
- Pricing & Payment Terms: Competitive pricing aligned with quality standards, alongside flexible payment arrangements.
Innovations & Trends in Packaging for Metronidazole
Advancements include stability-enhancing plastic formulations, environmentally sustainable materials, and smart packaging with serialization to prevent counterfeiting. Suppliers investing in such innovations tend to offer added value, especially for export markets with strict regulatory oversight.
Regulatory & Quality Assurance Aspects
All suppliers should offer validated processes, comprehensive documentation, and batch traceability. The FDA-approved suppliers often undergo rigorous audits, ensuring adherence to international standards. Moreover, suppliers offering tamper-proof, child-resistant, or moisture-proof containers better align with regulatory expectations and consumer safety.
Conclusion
Sourcing metronidazole in plastic containers involves evaluating tiered options — from major API producers providing finished packaged products to specialized CMOs offering tailored packaging solutions. Ensuring compliance with regulatory standards, high product quality, and resilient supply chains will be decisive in selecting optimal suppliers.
Key Takeaways
- Leading manufacturers like Zhejiang Huahai, Zydus Cadila, and Hubei Bestdrug provide high-quality metronidazole in plastic containers, often suitable for global markets.
- CMOs such as Famar and Neolab Pharmaceuticals extend flexible, compliant packaging capabilities, vital for customized formulations.
- Supplier selection should prioritize regulatory compliance, container compatibility, and reliable logistics.
- Innovations in packaging, including environmentally sustainable plastics and smart serialization, are gaining prominence.
- Establishing long-term partnerships ensures supply stability amid fluctuating global demands.
Frequently Asked Questions (FAQs)
1. What are the primary types of plastics used for packaging metronidazole?
HDPE (High-Density Polyethylene) and PET (Polyethylene Terephthalate) are commonly used due to their chemical inertness, durability, and compliance with pharmaceutical standards.
2. How can I verify the regulatory compliance of a supplier offering metronidazole in plastic containers?
Request certification documentation such as GMP certificates, FDA approvals, and dossier submissions demonstrating manufacturing practices and adherence to international standards.
3. Are there environmental considerations when choosing plastic containers for pharmaceuticals?
Yes. Preferably, suppliers should offer recyclable or biodegradable plastics in line with sustainability initiatives, ensuring minimal environmental impact without compromising safety.
4. What packaging features are critical for metronidazole in plastic containers?
Child resistance, tamper evidence, moisture barriers, and secure sealing are essential features that ensure safety and stability.
5. How do supply chain disruptions impact sourcing of metronidazole in plastic containers?
Disruptions can lead to shortages; partnering with multiple verified suppliers and maintaining adequate inventory levels are strategies to mitigate risks.
Sources:
[1] Pharmaceutical Technology. "Packaging options for oral solid and liquid drugs."
[2] Global Data. “Top manufacturers of metronidazole API and formulations.”
[3] WHO Guidelines. “Good Manufacturing Practices (GMP) for pharmaceutical products.”
