PRODUCT NAME: GEHUMANISEERD IMMUNOGLOBULINE, WELKE EEN HUMANE ACCEPTOR GRONDSTRUCTUURREGIO EN KABAT COMPLEMENTARITEITSBEPALENDE REGIO'S (CDRS) VAN EEN DONOR IMMUNOGLOBULINE VAN DE MUIS HEEFT, WAARIN A) DE HUMANE ACCEPTOR LG LICHTE KETEN GRONDSTRUCTUURSEQUENTIE ZODANIG IS GEKOZEN DAT DEZE MEER DAN 70% IDENTITEIT HEEFT MET DE RESPECTIEVE DONORSEQUENTIE VAN DE MUIS; EN B) DE HUMANE ACCEPTOR LG ZWARE KETEN GRONDSTRUCTUURSEQUENTIE ZODANIG IS GEKOZEN DAT DEZE TEN MINSTE 65% IDENTITEIT HEEFT MET DE RESPECTIEVE DONORSEQUENTIE VAN DE MUIS; EN C) DE CONSTANTE REGIO VAN DE LICHTE KETEN WORDT GECODEERD DOOR EEN GEN VOOR EEN KAPPA CONSTANTE REGIO; D) DE CONSTANTE REGIO VAN DE ZWARE KETEN WORDT GECODEERD
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