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Serving leading biopharmaceutical companies globally:

Merck
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Fuji
AstraZeneca
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Teva
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Farmers Insurance
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Generated: January 19, 2018

DrugPatentWatch Database Preview

Details for Patent: RE38506

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Summary for Patent: RE38506
Title: Potent inducers of terminal differentiation and methods of use thereof
Abstract:The present invention provides the compound having the structure: ##STR1## wherein each of R.sub.1 and R.sub.2 are independently the same as or different from each other; when R.sub.1 and R.sub.2 are the same, each is a substituted or unsubstituted arylamino, cycloalkylamino, pyridineamino, piperidino, 9-purine-6-amine, or thiozoleamino group; when R.sub.1 and R.sub.2 are different, R.sub.1 =R.sub.3 --N--R.sub.4, wherein each of R.sub.3 and R.sub.4 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted, branched or unbranched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy, or pyridine group, or R.sub.3 and R.sub.4 bond together to form a piperidine group and R.sub.2 is a hydroxylamino, hydroxyl, amino, alkylamino, dialkylamino or alkyloxy group; and n is an integer from about 4 to about 8. The present invention also provides a method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells. Moreover, the present invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells. Lastly, the present invention provides a pharmaceutical composition and a therapeutically acceptable amount of the compound above.
Inventor(s): Breslow; Ronald (Englewood, NJ), Marks; Paul A. (Bridgewater, CT), Rifkind; Richard A. (New York, NY), Jursic; Branko (New Orleans, LA)
Assignee: Sloan-Kettering Institute for Cancer Research (New York, NY) The Trustees of Columbia University in the City of New York (New York, NY)
Application Number:10/004,411
Patent Claim Types:
see list of patent claims
Compound; Composition;

Drugs Protected by US Patent RE38506

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Patents Family Members for US Patent RE38506

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 183185 ➤ Subscribe
Austria 253906 ➤ Subscribe
Australia 2647495 ➤ Subscribe
Australia 2870392 ➤ Subscribe
Australia 6206396 ➤ Subscribe
Australia 668696 ➤ Subscribe
Australia 692561 ➤ Subscribe
Australia 708115 ➤ Subscribe
Canada 2120619 ➤ Subscribe
Canada 2190765 ➤ Subscribe
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving leading biopharmaceutical companies globally:

Johnson and Johnson
Merck
UBS
Boehringer Ingelheim
McKesson
Chubb
Farmers Insurance
Express Scripts
US Department of Justice

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