Details for Patent: 5,585,397
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Summary for Patent: 5,585,397
Title: | Sulfonamide inhibitors of aspartyl protease |
Abstract: | The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity. |
Inventor(s): | Tung; Roger D. (Arlington, MA), Murcko; Mark A. (Holliston, MA), Bhisetti; Govinda R. (Lexington, MA) |
Assignee: | Vertex Pharmaceuticals, Incorporated (Cambridge, MA) |
Application Number: | 08/142,327 |
Patent Claim Types: see list of patent claims | Compound; Composition; |
Drugs Protected by US Patent 5,585,397
Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
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>Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
Foreign Priority and PCT Information for Patent: 5,585,397
PCT Information | |||
PCT Filed | September 07, 1993 | PCT Application Number: | PCT/US93/08458 |
PCT Publication Date: | March 17, 1994 | PCT Publication Number: | WO94/05639 |
International Family Members for US Patent 5,585,397
Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
---|---|---|---|---|---|
African Regional IP Organization (ARIPO) | 390 | ⤷ Try a Trial | |||
African Regional IP Organization (ARIPO) | 9300572 | ⤷ Try a Trial | |||
African Regional IP Organization (ARIPO) | 950 | ⤷ Try a Trial | |||
>Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |