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Generated: October 24, 2017

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Details for Patent: RE29835

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Summary for Patent: RE29835

Title: 1,2,4-Triazole nucleosides
Abstract:As antiviral agents and intermediates therefor, 3-substituted 1-(.beta.-D-glycosyl)-1,2,4-triazoles, O-acylated analogs thereof, and 5'- and 3',5'-cyclic phosphates of the triazole nucleosides, "glycosyl" being .[.a pentofuranosyl moiety, preferably one whose 2'-oxygen is trans to the triazole aglycon, e.g., xylofuranosyl,.]. ribofuranosyl, .[.2-0-methylribofuranosyl, etc.,.]. the triazole aglycon being 3-substituted with cyano, methylcarboxylate, carboxamidoxime, carboxamido-, thiocarboxamido, or carboxamidine. Preparation of these nucleosides is by silylation of the substituted triazole followed by glycosylation with the appropriate blocked glycosyl halide. Alternatively, acid-catalyzed fusion of the requisite 1,2,4-triazole with an O-acylated pentofuranose yields the nucleosides.
Inventor(s): Witkowski; Joseph T. (Laguna Niguel, CA), Robins; Roland K. (Santa Ana, CA)
Assignee: ICN Pharmaceuticals (Irvine, CA)
Application Number:05/782,294
Patent Claim Types:
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International Patent Family for Patent: RE29835

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Argentina199463► Subscribe
Argentina205339► Subscribe
Argentina207138► Subscribe
Argentina224992► Subscribe
Austria336199► Subscribe
AustriaA465772► Subscribe
Australia4215772► Subscribe
Australia461900► Subscribe
Australia6670874► Subscribe
Australia7914475► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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