Details for Patent: RE29835
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Summary for Patent: RE29835
Title: | 1,2,4-Triazole nucleosides |
Abstract: | As antiviral agents and intermediates therefor, 3-substituted 1-(.beta.-D-glycosyl)-1,2,4-triazoles, O-acylated analogs thereof, and 5'- and 3',5'-cyclic phosphates of the triazole nucleosides, "glycosyl" being .[.a pentofuranosyl moiety, preferably one whose 2'-oxygen is trans to the triazole aglycon, e.g., xylofuranosyl,.]. ribofuranosyl, .[.2-0-methylribofuranosyl, etc.,.]. the triazole aglycon being 3-substituted with cyano, methylcarboxylate, carboxamidoxime, carboxamido-, thiocarboxamido, or carboxamidine. Preparation of these nucleosides is by silylation of the substituted triazole followed by glycosylation with the appropriate blocked glycosyl halide. Alternatively, acid-catalyzed fusion of the requisite 1,2,4-triazole with an O-acylated pentofuranose yields the nucleosides. |
Inventor(s): | Witkowski; Joseph T. (Laguna Niguel, CA), Robins; Roland K. (Santa Ana, CA) |
Assignee: | ICN Pharmaceuticals (Irvine, CA) |
Application Number: | 05/782,294 |
Patent Claim Types: see list of patent claims | Compound; |
Drugs Protected by US Patent RE29835
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International Family Members for US Patent RE29835
Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
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Argentina | 199463 | ⤷ Try a Trial | |||
Argentina | 205339 | ⤷ Try a Trial | |||
Argentina | 207138 | ⤷ Try a Trial | |||
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