Details for Patent: 9,943,538

Summary for Patent: 9,943,538

Title:	2′-methoxy substituted oligomeric compounds and compositions for use in gene modulations
Abstract:	Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modified sugar and/or backbone modification. In some embodiments the modification is a 2′-OCH3 substituent group on a sugar moiety. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide of the oligomer has a modified sugar and/or backbone modification.
Inventor(s):	Stanley T. Crooke
Assignee:	Ionis Pharmaceuticals Inc
Application Number:	US15/851,464
Patent Claim Types: see list of patent claims	Composition;

Drugs Protected by US Patent 9,943,538

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate

International Family Members for US Patent 9,943,538

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Austria	292141
Australia	2003213120
Australia	2003248708
Australia	2003251524
Australia	2003287464
Australia	2003287501