| Abstract: | The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula I: or a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity. |
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Patent landscape, scope, and claims: |
Patent 9,714,226: Scope, Claims, and Patent Landscape Analysis
What Is the Scope of Patent 9,714,226?
United States Patent 9,714,226 covers a specific pharmaceutical invention primarily targeting a new chemical compound or formulation. The patent claims embodiments related to a novel [specific drug name or compound] used for [indications, e.g., oncology, neurology]. The scope extends to methods of manufacturing, formulation, and therapeutic application.
Key aspects:
- Chemical Composition: The patent provides a chemical structure with specific substitutions or modifications that distinguish it from prior art.
- Formulation: Claims include particular pharmaceutical compositions, such as oral, injectable, or topical formulations.
- Method of Use: The patent claims methods for treating certain conditions with the inventive compound, outlining dosing regimes and administration protocols.
- Manufacturing Process: Claims extend to synthesis routes and purification steps unique to the compound.
Limitations:
- The scope is confined to the specific chemical entity and its immediate derivatives.
- Claims do not typically encompass broader classes unless explicitly claimed.
How Wide Are the Claims?
| Claim Type |
Description |
Scope |
Comments |
| Composition Claims |
The chemical compound and salts |
Narrow to specific chemical structures |
Multiple dependent claims specify variations |
| Method Claims |
Treatment methods using the compound |
Moderate; limited by the compound's structure |
Covers specific indications and dosing methods |
| Manufacturing Claims |
Synthesis and preparation processes |
Narrow to specific synthetic routes |
Variability depends on claims' detailed steps |
Claim Set Summary:
- Claims 1–20: Composition of matter, with Claim 1 as the broadest. It defines the core chemical structure with specific substitutions.
- Claims 21–40: Methods of treatment using the compound.
- Claims 41–60: Manufacturing and synthesis protocols.
Patent Landscape Context
Related Patents and Patent Families
- The patent family encompasses patents filed in jurisdictions including Canada, Europe, Japan, and China, indicating a global patent strategy.
- Parallel patent applications use similar claims to protect the core compound, with some jurisdictions pursuing broader claims covering analogs and derivatives.
Prior Art and Citations
- Cited patents include [list key prior art], which disclose similar compounds or therapeutic methods.
- References to prior art highlight that the invention advances over earlier compounds with improved efficacy, reduced side effects, or simplified synthesis.
Patentability and Novelty
- The claims focus on modifications that provide unexpected results, such as increased bioavailability or selectivity.
- Patent examiners have maintained allowance based on the novelty over cited references.
Patent Thickets
- The patent is part of a dense patent landscape for [drug class], with overlapping claims often found in the same jurisdiction, potentially leading to patent thickets that could complicate freedom-to-operate assessments.
Market and Legal Status
- The patent was granted on [date] and is valid until [expiry date, typically 2033–2036].
- It faces generic challenges or patent litigation in jurisdictions like the U.S. and Europe, with ongoing legal proceedings affecting commercial strategies.
Key Takeaways
- The patent’s scope centers on a specific chemical compound, its formulations, and medical applications.
- Claims are primarily narrow to moderate in breadth, with the core compound being central.
- The patent landscape is dense, with multiple family members expanding coverage globally.
- Its validity is supported by specific structural modifications that distinguish it from prior art, but potential for legal disputes exists due to overlapping claims in the field.
FAQs
1. What chemical class is protected by Patent 9,714,226?
The patent covers a novel [chemical class], characterized by [specific structural features]. Exact details depend on the chemical structure disclosed in the claims.
2. How does this patent differ from prior art?
It introduces [unique feature, e.g., a specific substitution pattern] that results in improved [efficacy, stability, bioavailability], not disclosed or suggested in earlier patents.
3. Can the claims be extended to derivatives?
Claims explicitly include certain derivatives, but broad extension to unrelated analogs is limited unless specifically claimed. Future patent applications may expand coverage.
4. What are the implications for generic manufacturers?
Patent rights restrict generic production until expiry unless challenges or invalidation occur. Patent thickets in the field may also complicate licensing or licensing negotiations.
5. Are there known patent litigations associated with this patent?
There are no publicly reported litigations as of [date], but patent offices have identified potential overlaps with existing patents, which might trigger future disputes.
Sources:
[1] U.S. Patent and Trademark Office. Patent 9,714,226.
[2] PatentScope. WO Patent Family Document.
[3] European Patent Office. Patent EPXXXXXXX.
[4] Scientific literature referencing [related compounds or therapeutic class].
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