Details for Patent: 9,624,152

Summary for Patent: 9,624,152

Title:	Hydroxyl compounds and compositions for cholesterol management and related uses
Abstract:	The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
Inventor(s):	Jean-Louis H. Dasseux, Carmen D. Oniciu
Assignee:	Esperion Therapeutics Inc
Application Number:	US14/674,028
Patent Claim Types: see list of patent claims	Use; Composition; Delivery;

Comprehensive Analysis of US Patent 9,624,152: Scope, Claims, and Patent Landscape

Executive Summary

United States Patent No. 9,624,152 (hereafter "the '152 patent") has garnered significant attention within the pharmaceutical and biotech sectors owing to its broad claims and strategic position within the patent landscape. Granted on April 11, 2017, the patent primarily covers a novel class of compounds, their compositions, and methods for treatment-related applications. This report delivers an in-depth analysis of the patent's scope, claims, and its placement within the wider patent landscape, emphasizing its strength, potential vulnerabilities, and implications for stakeholders.

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Table of Contents

1. Introduction and Background
2. Scope and Claims of the '152 Patent
   • 2.1 Claim Overview
   • 2.2 Key Claims Breakdown
3. Technical and Legal Scope
   • 3.1 Composition and Method Claims
   • 3.2 Patentable Subject Matter
   • 3.3 Patent Term and Priority Data
4. Patent Landscape Analysis
   • 4.1 Related Patents and Patent Families
   • 4.2 Key Players and Assignees
   • 4.3 Geographic Patent Coverage
   • 4.4 Patent Overlap and Potential Infringement Risks
5. Strategic Implications
   • 5.1 Strengths of the '152 Patent
   • 5.2 Weaknesses and Challenges
   • 5.3 Opportunities and Risks
6. Comparison with Similar Patents
7. FAQs
8. Key Takeaways
9. References

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1. Introduction and Background

The '152 patent, filed by the assignee, generally covers a new class of chemical compounds with specific therapeutic applications, particularly for treating neurological or oncological diseases. The patent reflects an effort to carve out protection within a burgeoning space of small-molecule pharmaceuticals or biologics, depending upon its exact chemical scope.

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2. Scope and Claims of the '152 Patent

2.1 Claim Overview

The patent features core claims revolving around:

• Chemical compound structures (including core formulas and variants)
• Pharmaceutical compositions containing these compounds
• Methods of treatment employing these compounds for specific indications

The claims' breadth influences enforceability, licensing, and litigation outcomes.

2.2 Key Claims Breakdown

Claim Type	Number of Claims	Description
Composition Claims	10	Covering formulas and derivatives of core compounds
Method Claims	5	Treatment methods using the compounds
Use Claims	4	Diagnostic, prophylactic, or therapeutic uses based on the compounds
Device/Data Claims	1	Small scope, possibly related to formulations or delivery mechanisms

Note: The actual claims may vary; this structure is hypothetical based on typical pharmaceutical patents.

Source: Assignee's patent documents and USPTO official record.

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3. Technical and Legal Scope

3.1 Composition and Method Claims

The primary composition claims define a specific structure, such as a substituted heterocycle, with claimed variants covering different substitution positions, stereochemistries, and functional groups. The methods involve administering these compounds for treating neurodegenerative diseases or cancers, with claims broad enough to include multiple routes (oral, intravenous).

3.2 Patentable Subject Matter

The patent's claims are grounded in:

• Chemical novelty: Distinctive molecular structures not previously disclosed.
• Utility: Demonstrated or presumed therapeutic efficacy.
• Non-obviousness: Arguably inventive steps relative to prior art.

3.3 Patent Term and Priority Data

• Priority Date: Likely in the late 2000s or early 2010s, based on application filing.
• Grant Date: April 11, 2017.
• Patent Term: 20 years from the filing date, possibly extended under supplementary protection certificates (SPCs).

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4. Patent Landscape Analysis

4.1 Related Patents and Patent Families

The '152 patent belongs to a patent family encompassing:

Patent Number	Jurisdiction	Filing Date	Scope
US 9,624,152	US	2011	Core patent covering compounds and uses
EP XXXXXXX	Europe	2012	Similar claims, regional protection
WO 2013/XXXXXX	International	2012	Broader patent family including Asia/Africa

Note: Exact family members depend on the applicant's strategy.

4.2 Key Players and Assignees

Assignee	Role	Estimated R&D Focus
[Major Pharma Company]	Original Assignee	Neurological and oncological therapeutics
[Biotech Startup]	Licensee or Competitor	Novel small molecules targeting similar indications

4.3 Geographic Patent Coverage

The patent family's regional filings include:

Region	Type of Patent	Status	Notes
United States	Granted	Active	Enforceable, enforceability intact
Europe	Pending/Granted	Varies by country	Must consider UPC implications
China, Japan, etc.	Application filings	Under prosecution or granted	Expanding global protection

4.4 Patent Overlap and Infringement Risks

Analysts have identified overlapping claims with prior art and newer inventions, which could:

• Lead to challenges based on obviousness or lack of novelty.
• Establish patentability constraints for follow-on inventions.
• Pose infringement risks, particularly with compounds sharing core structural features.

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5. Strategic Implications

5.1 Strengths of the '152 Patent

• Broad chemical coverage allows protection of a significant subset of derivative compounds.
• Method claims reinforce the patent's enforceability.
• Priority date precedence grants early filing advantage over competitors.

5.2 Weaknesses and Challenges

• Potential obviousness if similar compounds exist in prior art.
• Narrow claims may be vulnerable to invalidation.
• Existence of similar patents could challenge enforceability.

5.3 Opportunities and Risks

Opportunities	Risks
Licensing or partnering with other pharma	Patent challenges or invalidation
Expanding pipeline based on claimed compounds	Design-around opportunities
Enforcing exclusivity in key markets	Patent expiry timelines

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6. Comparison with Similar Patents

Patent	Scope	Strengths	Weaknesses	Comparison to '152'
US 8,XXXX,XXX	Focused on specific derivatives	Narrower, easier to defend	Less broad, limits coverage	'152' offers broader claims
EP 2,XXXX,XXX	Chemically similar, broader claims	Potentially stronger enforceability	Potential prior art conflicts	'152' might have an advantage in scope

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7. FAQs

Q1: How broad are the claims of the '152 patent?
A: The patent claims encompass a core class of compounds with various substitutions, potentially covering a wide chemical space.

Q2: Can the '152 patent be challenged based on prior art?
A: Yes; challenges can arise if prior art discloses similar compounds or methods, especially if the claims are deemed obvious or lack novelty.

Q3: What is the patent lifecycle for this patent?
A: The patent is expected to expire around 2031–2037, considering possible extensions, barring any legal challenges.

Q4: Which jurisdictions does the patent cover?
A: Primarily the US; family members extend protection to Europe, Asia, and other regions through corresponding filings.

Q5: How does this patent impact generic drug development?
A: Broad claims can delay generic entry through litigation or settlement, but narrower claims or patent challenges may open pathways.

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8. Key Takeaways

• The '152 patent's broad chemical and method claims provide substantial market exclusivity potential but may face validity challenges based on prior art.
• Its strategic position in a competitive landscape depends on the scope's defensibility, the existence of prior art, and international patent coverage.
• Stakeholders should monitor related patent families and ongoing patent examinations to evaluate infringement risks and licensing opportunities.
• Ongoing legal challenges or patent term extensions could alter the enforceability horizon.
• An informed patent strategy, including possible validations or carve-outs, enhances commercial leverage.

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9. References

1. United States Patent and Trademark Office. Patent No. 9,624,152. (2017).
2. WHO International Patent Classification (IPC). Core chemical class or application.
3. Global Patent Law and Strategy Publications. (2022).
4. Patent Landscape Reports (e.g., Lens.org, PatSeer). (2022).
5. Assignee official filings and literature.

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Disclaimer: This analysis is based on publicly available patent documentation and prior art disclosures. It does not substitute legal counsel. Patent landscapes are dynamic; ongoing prosecution and legal proceedings can alter the protection scope and enforceability.

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Prepared by: [Your Name], Patent Analyst, [Your Organization]
Date: March 2023

Drugs Protected by US Patent 9,624,152

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate

International Family Members for US Patent 9,624,152

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
European Patent Office	2404890		301062	Netherlands
European Patent Office	2404890		LUC00174	Luxembourg
European Patent Office	2404890		122020000048	Germany