Details for Patent: 9,416,361
Summary for Patent: 9,416,361
| Title: | Splice-region antisense composition and method |
| Abstract: | Antisense compositions targeted against an mRNA sequence coding for a selected protein, at a region having its 5′ end from 1 to about 25 base pairs downstream of a normal splice acceptor junction in the preprocessed mRNA, are disclosed. The antisense compound is RNase-inactive, and is preferably a phosphorodiamidate-linked morpholino oligonucleotide. Such targeting is effective to inhibit natural mRNA splice processing, produce splice variant mRNAs, and inhibit normal expression of the protein. |
| Inventor(s): | Patrick L. Iversen, Robert Hudziak |
| Assignee: | Biopharma Credit PLC |
| Application Number: | US14/535,098 |
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Patent Claim Types: see list of patent claims | Compound; |
Drugs Protected by US Patent 9,416,361
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International Family Members for US Patent 9,416,361
| Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
|---|---|---|---|---|---|
| Austria | 467688 | ⤷ Start Trial | |||
| Austria | 510914 | ⤷ Start Trial | |||
| Austria | 540116 | ⤷ Start Trial | |||
| >Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |
