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Serving leading biopharmaceutical companies globally:

Johnson and Johnson
Dow
Chubb
Covington
AstraZeneca
Teva
Merck
Chinese Patent Office
Moodys
Federal Trade Commission

Generated: January 16, 2018

DrugPatentWatch Database Preview

Details for Patent: 9,353,103

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Which drugs does patent 9,353,103 protect, and when does it expire?

Patent 9,353,103 protects OLYSIO and is included in one NDA.

This patent has fifty-one patent family members in thirty-eight countries.
Summary for Patent: 9,353,103
Title:Macrocyclic inhibitors of hepatitis C virus
Abstract: Inhibitors of HCV replication of formula (I) ##STR00001## and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond; X is N, CH and where X bears a double bond it is C; R.sup.1 is --OR.sup.7, --NH--SO.sub.2R.sup.8; R.sup.2 is hydrogen, and where X is C or CH, R.sup.2 may also be C.sub.1-6alkyl; R.sup.3 is hydrogen, C.sub.1-6alkyl, C.sub.1-6alkoxyC.sub.1-6alkyl, C.sub.3-7cycloalkyl; R.sup.4 is aryl or Het; n is 3, 4, 5, or 6; R.sup.5 is halo, C.sub.1-6alkyl, hydroxy, C.sub.1-6alkoxy, phenyl, or Het; R.sup.6 is C.sub.1-6alkoxy, or dimethylamino; R.sup.7 is hydrogen; aryl; Het; C.sub.3-7cycloalkyl optionally substituted with C.sub.1-6alkyl; or C.sub.1-6alkyl optionally substituted with C.sub.3-7cycloalkyl, aryl or with Het; R.sup.8 is aryl; Het; C.sub.3-7cycloalkyl optionally substituted with C.sub.1-6alkyl; or C.sub.1-6alkyl optionally substituted with C.sub.3-7cycloalkyl, aryl or with Het; aryl is phenyl optionally substituted with one, two or three substituents; Het is a 5 or 6 membered saturated, partially unsaturated or completely unsaturated heterocyclic ring containing 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, and being optionally substituted with one, two or three substituents; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I). Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.
Inventor(s): Simmen; Kenneth Alan (Tervuren, BE), De Kock; Herman Augustinus (Arendonk, BE), Raboisson; Pierre Jean-Marie Bernard (Sterrebeek, BE), Hu; Lili (Mechelen, BE), Tahri; Abdellah (Anderlecht, BE), Surleraux; Dominique Louis Nestor Ghislain (Braine-le-chateau, BE), Nilsson; Karl Magnus (Goteborg, SE), Samuelsson; Bengt Bertil (Skarholmen, SE), Rosenquist; Asa Annica Kristina (Huddinge, SE), Ivanov; Vladimir (Moscow, RU), Pelcman; Mikael (Alvsjo, SE), Belfrage; Anna Karin Gertrud Linea (Uppsala, SE), Johansson; Per-Ola Mikael (Huddinge, SE), Vendeville; Sandrine Marie Helene (Etterbeek, BE)
Assignee: Janssen Sciences Ireland UC (Little Island, Co. Cork, IE) Medivir AB (Huddinge, SE)
Application Number:14/684,649
Patent Claim Types:
see list of patent claims

Drugs Protected by US Patent 9,353,103

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Janssen Prods OLYSIO simeprevir sodium CAPSULE;ORAL 205123-001 Nov 22, 2013 RX Yes Yes ➤ Subscribe ➤ Subscribe METHOD OF TREATING HEPATITIS C ➤ Subscribe
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Non-Orange Book US Patents Family Members for Patent 9,353,103

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
8,754,106 Macrocyclic inhibitors of hepatitis C virus ➤ Subscribe
8,148,399 Macrocyclic inhibitors of hepatitis C virus ➤ Subscribe
8,153,800 Macrocyclic inhibitors of hepatitis C virus ➤ Subscribe
9,040,562 Macrocyclic inhibitors of hepatitis C virus ➤ Subscribe
8,741,926 Macrocyclic inhibitors of hepatitis C virus ➤ Subscribe
8,349,869 Macrocylic inhibitors of hepatitis C virus ➤ Subscribe
9,623,022 Macrocyclic inhibitors of hepatitis C virus ➤ Subscribe
Patent No. Title Estimated Patent Expiration

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International Patents Family Members for US Patent 9,353,103

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Serving leading biopharmaceutical companies globally:

Express Scripts
Daiichi Sankyo
Healthtrust
Argus Health
Chinese Patent Office
US Army
Federal Trade Commission
Covington
Fuji

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