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Details for Patent: 8,999,638

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Which drugs does patent 8,999,638 protect, and when does it expire?

Patent 8,999,638 protects FANAPT and is included in one NDA.

This patent has ten patent family members in seven countries.

Summary for Patent: 8,999,638

Title:	Method of treatment based on polymorphisms of the KCNQ1 gene
Abstract:	The invention provides methods for the administration of compounds capable of prolonging a QTc interval and methods for predicting whether an individual is predisposed to such QTc prolongation.
Inventor(s):	Wolfgang; Curt D. (Germantown, MD), Polymeropoulos; Mihael H. (Potomac, MD)
Assignee:	Vanda Pharmaceuticals, Inc. (Washington, DC)
Application Number:	13/263,074
Patent Claim Types: see list of patent claims	Use;

Drugs Protected by US Patent 8,999,638

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Patent Submitted
Vanda Pharms Inc	FANAPT	iloperidone	TABLET;ORAL	022192-001	May 6, 2009	AB	RX	Yes	Yes						DOSAGE MODIFICATION TO REDUCE RISKS ASSOCIATED WITH QT PROLONGATION NOT INDUCED BY OTHER DRUGS DURING TREATMENT WITH ILOPERIDONE
Vanda Pharms Inc	FANAPT	iloperidone	TABLET;ORAL	022192-002	May 6, 2009	AB	RX	Yes	No						DOSAGE MODIFICATION TO REDUCE RISKS ASSOCIATED WITH QT PROLONGATION NOT INDUCED BY OTHER DRUGS DURING TREATMENT WITH ILOPERIDONE
Vanda Pharms Inc	FANAPT	iloperidone	TABLET;ORAL	022192-003	May 6, 2009	AB	RX	Yes	No						DOSAGE MODIFICATION TO REDUCE RISKS ASSOCIATED WITH QT PROLONGATION NOT INDUCED BY OTHER DRUGS DURING TREATMENT WITH ILOPERIDONE
Vanda Pharms Inc	FANAPT	iloperidone	TABLET;ORAL	022192-004	May 6, 2009	AB	RX	Yes	No						DOSAGE MODIFICATION TO REDUCE RISKS ASSOCIATED WITH QT PROLONGATION NOT INDUCED BY OTHER DRUGS DURING TREATMENT WITH ILOPERIDONE

Foreign Priority and PCT Information for Patent: 8,999,638

PCT Information
PCT Filed	April 05, 2010	PCT Application Number:	PCT/US2010/029921
PCT Publication Date:	October 14, 2010	PCT Publication Number:	WO2010/117931

Non-Orange Book US Patents Family Members for Patent 8,999,638

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No.	Title	Estimated Patent Expiration
9,157,121	Method of treatment based on polymorphisms of the KCNQ1 gene

International Patents Family Members for US Patent 8,999,638

Country	Document Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Canada	2757713
European Patent Office	2417267
European Patent Office	3023506
Spain	2604102