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Serving 500+ biopharmaceutical companies globally:

UBS
Merck
AstraZeneca
Mallinckrodt
Cantor Fitzgerald
US Army
Fish and Richardson
Healthtrust
Chubb
Daiichi Sankyo

Generated: June 23, 2017

DrugPatentWatch Database Preview

Details for Patent: 8,946,235

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Which drugs does patent 8,946,235 protect, and when does it expire?


Patent 8,946,235 protects TAGRISSO and is included in one NDA.

This patent has sixty-nine patent family members in thirty-three countries.

Summary for Patent: 8,946,235

Title:2-(2,4,5-substituted-anilino) pyrimidine compounds
Abstract: The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using such compounds and salts thereof.
Inventor(s): Butterworth; Sam (Cheshire, GB), Finlay; Maurice Raymond Verschoyle (Cheshire, GB), Ward; Richard Andrew (Cheshire, GB), Redfearn; Heather Marie (Cheshire, GB)
Assignee: AstraZeneca AB (Sodertalje, SE)
Application Number:13/557,871
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Astrazeneca Pharms
TAGRISSO
osimertinib mesylate
TABLET;ORAL208065-001Nov 13, 2015RXYesNo8,946,235► SubscribeYY TREATMENT OF PATIENTS WITH METASTATIC EPIDERMAL GROWTH FACTORE RECEPTOR (EGFR) T790M MUTATION-POSITIVE NON-SMALL CELL LUNG CANCER (NSCLC), WHO HAVE PROGRESSED ON OR AFTER EGFR TKI THERAPY
Astrazeneca Pharms
TAGRISSO
osimertinib mesylate
TABLET;ORAL208065-002Nov 13, 2015RXYesYes8,946,235► SubscribeYY TREATMENT OF PATIENTS WITH METASTATIC EPIDERMAL GROWTH FACTORE RECEPTOR (EGFR) T790M MUTATION-POSITIVE NON-SMALL CELL LUNG CANCER (NSCLC), WHO HAVE PROGRESSED ON OR AFTER EGFR TKI THERAPY
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International Patent Family for Patent: 8,946,235

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Israel242284► Subscribe
Israel242279► Subscribe
Israel242278► Subscribe
Israel229199► Subscribe
HungaryE026429► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving 500+ biopharmaceutical companies globally:

UBS
Merck
Boehringer Ingelheim
Baxter
Teva
Healthtrust
Argus Health
Novartis
Covington
Farmers Insurance

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

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