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Serving leading biopharmaceutical companies globally:

Deloitte
Farmers Insurance
Fuji
Fish and Richardson
QuintilesIMS
Teva
Covington
Merck
Moodys
Mallinckrodt

Generated: December 11, 2017

DrugPatentWatch Database Preview

Details for Patent: 8,946,235

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Which drugs does patent 8,946,235 protect, and when does it expire?


Patent 8,946,235 protects TAGRISSO and is included in one NDA.

This patent has seventy-one patent family members in thirty-four countries.

Summary for Patent: 8,946,235

Title:2-(2,4,5-substituted-anilino) pyrimidine compounds
Abstract: The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using such compounds and salts thereof.
Inventor(s): Butterworth; Sam (Cheshire, GB), Finlay; Maurice Raymond Verschoyle (Cheshire, GB), Ward; Richard Andrew (Cheshire, GB), Redfearn; Heather Marie (Cheshire, GB)
Assignee: AstraZeneca AB (Sodertalje, SE)
Application Number:13/557,871
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Patent Submitted Product Substance Delist Req. Patented / Exclusive Use
Astrazeneca PharmsTAGRISSOosimertinib mesylateTABLET;ORAL208065-001Nov 13, 2015RXYesNo► Subscribe► Subscribe► SubscribeYYTREATMENT OF PATIENTS WITH METASTATIC EPIDERMAL GROWTH FACTORE RECEPTOR (EGFR) T790M MUTATION-POSITIVE NON-SMALL CELL LUNG CANCER (NSCLC), WHO HAVE PROGRESSED ON OR AFTER EGFR TKI THERAPY
Astrazeneca PharmsTAGRISSOosimertinib mesylateTABLET;ORAL208065-002Nov 13, 2015RXYesYes► Subscribe► Subscribe► SubscribeYYTREATMENT OF PATIENTS WITH METASTATIC EPIDERMAL GROWTH FACTORE RECEPTOR (EGFR) T790M MUTATION-POSITIVE NON-SMALL CELL LUNG CANCER (NSCLC), WHO HAVE PROGRESSED ON OR AFTER EGFR TKI THERAPY
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Non-Orange Book Patents for Patent: 8,946,235

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
9,732,0582-(2,4,5-substituted-anilino)pyrimidine compounds► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Because of the complexity of determining patent expiration dates it is advisable to have patent counsel verify freedom to operate.

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International Patent Family for Patent: 8,946,235

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Peru17002014► Subscribe
New Zealand617393► Subscribe
Malaysia161925► Subscribe
Mexico2014000528► Subscribe
South Korea101691268► Subscribe
South Korea20140062181► Subscribe
South Korea101422619► Subscribe
South Korea20140047741► Subscribe
South Korea101410902► Subscribe
South Korea20140030089► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

UBS
Cipla
Moodys
Cantor Fitzgerald
Teva
Harvard Business School
Chinese Patent Office
Healthtrust
Federal Trade Commission
Boehringer Ingelheim

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