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Serving hundreds of leading biopharmaceutical companies globally:

Chinese Patent Office
QuintilesIMS
Fuji
Citi
Mallinckrodt
Colorcon
Farmers Insurance
Daiichi Sankyo
Medtronic

Generated: April 26, 2018

DrugPatentWatch Database Preview

Details for Patent: 8,642,608

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Which drugs does patent 8,642,608 protect, and when does it expire?

Patent 8,642,608 protects CAPRELSA and is included in one NDA.

This patent has fifty-three patent family members in thirty-three countries.
Summary for Patent: 8,642,608
Title:Quinazoline derivatives as VEGF inhibitors
Abstract: The invention relates to quinazoline derivatives of formula (I), wherein m is an integer from 1 to 3; R.sup.1 represents halogeno or C.sub.1-3alkyl; X.sup.1 represents --O--; R.sup.2 is selected from one of the following three groups: 1) C.sub.1-5alkylR.sup.3 (wherein R.sup.3 is piperidinyl-4-yl which may bear one or two substituents selected from hydroxy, halogeno, C.sub.1-4alkyl, C.sub.1-4hydroxyalkyl and C.sub.1-4alkoxy; 2) C.sub.2-5alkenylR.sup.3 (wherein R.sup.3 is as defined hereinbefore); 3) C.sub.2-5alkynylR.sup.3 (wherein R.sup.3 is as defined hereinbefore); and wherein any alkyl, alkenyl or alkynyl group may bear one or more substituents selected from hydroxy, halogeno and amino; and salts thereof; processes for their preparation, pharmaceutical compositions containing a compound of formula (I) or a pharmaceutically acceptable salt thereof as active ingredient. The compounds of formula (I) and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis. ##STR00001##
Inventor(s): Thomas; Andrew Peter (Macclesfield, GB), Stokes; Elaine Sophie Elizabeth (Macclesfield, GB), Hennequin; Laurent Francois Andre (Reims Cedex, FR)
Assignee: AstraZeneca AB (Sodertalje, SE)
Application Number:12/761,105
Patent Claim Types:
see list of patent claims
Use;

Drugs Protected by US Patent 8,642,608

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Genzyme Corp CAPRELSA vandetanib TABLET;ORAL 022405-001 Apr 6, 2011 RX Yes No ➤ Sign Up ➤ Sign Up FOR USE IN PATIENTS HAVING SYMPTOMATIC OR PROGRESSIVE MEDULLARY THYROID CANCER, WITH UNRESECTABLE LOCALLY ADVANCED OR METASTATIC DISEASE ➤ Sign Up
Genzyme Corp CAPRELSA vandetanib TABLET;ORAL 022405-002 Apr 6, 2011 RX Yes Yes ➤ Sign Up ➤ Sign Up FOR USE IN PATIENTS HAVING SYMPTOMATIC OR PROGRESSIVE MEDULLARY THYROID CANCER, WITH UNRESECTABLE LOCALLY ADVANCED OR METASTATIC DISEASE ➤ Sign Up
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Foreign Priority and PCT Information for Patent: 8,642,608

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
99402759Nov 5, 1999
99402877Nov 19, 1999

Non-Orange Book US Patents Family Members for Patent 8,642,608

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
7,173,038 Quinazoline derivatives as VEGF inhibitors ➤ Sign Up
9,040,548 Quinazoline derivatives as VEGF inhibitors ➤ Sign Up
Patent No. Title Estimated Patent Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Dow
McKesson
Johnson and Johnson
Mallinckrodt
Teva
Cantor Fitzgerald
Boehringer Ingelheim
UBS
Farmers Insurance

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