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Generated: September 15, 2019

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Details for Patent: 8,633,219

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Summary for Patent: 8,633,219
Title:Combination therapy
Abstract: The present invention relates to a combination therapy for treating an HIV infection or inhibiting integrase comprising (S)-6-(3-Chloro-2-fluorobenzyl)-1-(1-hydroxymethyl-2-methylpropyl)-7-meth- oxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ("Compound A") or a pharmaceutically acceptable solvate or salt thereof in combination with at least one other anti-HIV agent. In some embodiments of the present invention, the other anti-HIV agents are chosen from reverse transcriptase inhibitors and protease inhibitors. In certain embodiments of the present invention, the other anti-HIV agents are chosen from AZT, 3TC, PMPA, efavirenz, indinavir, nelfinavir, a combination of AZT/3TC, and a combination of PMPA/3TC. Since Compound A has a high inhibitory activity specific for integrases, when used in combinations with other anti-HIV agents it can provide a combination therapy with fewer side effects for humans.
Inventor(s): Matsuzaki; Yuji (Osaka, JP), Watanabe; Wataru (Osaka, JP), Ikeda; Satoru (Osaka, JP), Kano; Mitsuki (Osaka, JP)
Assignee: Japan Tobacco Inc. (Tokyo, JP)
Application Number:11/133,463
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 8,633,219
Patent Claim Types:
see list of patent claims
Use; Composition;

Drugs Protected by US Patent 8,633,219

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Gilead Sciences Inc GENVOYA cobicistat; elvitegravir; emtricitabine; tenofovir alafenamide fumarate TABLET;ORAL 207561-001 Nov 5, 2015 RX Yes Yes ➤ Sign Up ➤ Sign Up Y TREATMENT OF HIV INFECTION ➤ Sign Up
Gilead Sciences Inc STRIBILD cobicistat; elvitegravir; emtricitabine; tenofovir disoproxil fumarate TABLET;ORAL 203100-001 Aug 27, 2012 RX Yes Yes ➤ Sign Up ➤ Sign Up Y TREATMENT OF HIV INFECTION ➤ Sign Up
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

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International Family Members for US Patent 8,633,219

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office 1758581 ➤ Sign Up
European Patent Office 2229945 ➤ Sign Up
European Patent Office 2332538 ➤ Sign Up
European Patent Office 3287130 ➤ Sign Up
Japan 2008500386 ➤ Sign Up
Japan 4629104 ➤ Sign Up
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Johnson and Johnson
Argus Health
Harvard Business School
Julphar
Moodys
Boehringer Ingelheim

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