Details for Patent: 8,546,143
✉ Email this page to a colleague
Summary for Patent: 8,546,143
Title: | Compositions and methods for inhibiting expression of a target gene |
Abstract: | The present invention relates to a double-stranded ribonucleic acid (dsRNA) having a nucleotide sequence which is substantially identical to at least a part of a target gene and which is no more than 49, preferably less than 25, nucleotides in length, and which comprises a complementary (antisense) RNA strand having a 1 to 4 nucleotide overhang at the 3'-end and a blunt 5'-end. The invention further relates to a pharmaceutical composition comprising the dsRNA and a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for inhibiting the expression of a target gene, as well as for treating diseases caused by expression of the target gene, at low dosages (i.e., less than 5 milligrams, preferably less than 25 micrograms, per kg body weight per day). The invention also relates to methods for inhibiting the expression of a target gene, as well as methods for treating diseases caused by the expression of the gene. |
Inventor(s): | Kreutzer; Roland (Weidenberg, DE), Limmer; Stefan (Kulmbach, DE), Limmer; Sylvia (Kulmbach, DE), Hadwiger; Philipp (Bayreuth, DE) |
Assignee: | Alnylam Pharmaceuticals, Inc. (Cambridge, MA) |
Application Number: | 12/894,018 |
Patent Claim Types: see list of patent claims | Use; Compound; |
Drugs Protected by US Patent 8,546,143
Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
>Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
Foreign Priority and PCT Information for Patent: 8,546,143
Foriegn Application Priority Data | ||
Foreign Country | Foreign Patent Number | Foreign Patent Date |
Germany | 101 00 586 | Jan 9, 2001 |
Germany | 101 55 280 | Oct 26, 2001 |
Germany | 10 158 411 | Nov 29, 2001 |
Germany | 101 60 151 | Dec 7, 2001 |
International Family Members for US Patent 8,546,143
Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
---|---|---|---|---|---|
Austria | 222953 | ⤷ Try a Trial | |||
Austria | 297463 | ⤷ Try a Trial | |||
Austria | 328075 | ⤷ Try a Trial | |||
Austria | 418610 | ⤷ Try a Trial | |||
Austria | 460481 | ⤷ Try a Trial | |||
Australia | 2002229701 | ⤷ Try a Trial | |||
>Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |