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Last Updated: December 8, 2021

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Details for Patent: 8,497,277


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Summary for Patent: 8,497,277
Title:Inhibitors of Bruton's tyrosine kinase
Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
Inventor(s): Honigberg; Lee (San Francisco, CA), Verner; Erik (Belmont, CA), Pan; Zhengying (Austin, TX)
Assignee: Pharmacyclics, Inc. (Sunnyvale, CA)
Application Number:13/312,606
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 8,497,277
Patent Claim Types:
see list of patent claims
Use; Device; Delivery;

Drugs Protected by US Patent 8,497,277

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Pharmacyclics Inc IMBRUVICA ibrutinib CAPSULE;ORAL 205552-002 Dec 20, 2017 RX Yes No ⤷  Free Forever Trial ⤷  Free Forever Trial TREATMENT OF MANTLE CELL LYMPHOMA ⤷  Free Forever Trial
Pharmacyclics Inc IMBRUVICA ibrutinib CAPSULE;ORAL 205552-002 Dec 20, 2017 RX Yes No ⤷  Free Forever Trial ⤷  Free Forever Trial TREATMENT OF SMALL LYMPHOCYTIC LYMPHOMA ⤷  Free Forever Trial
Pharmacyclics Inc IMBRUVICA ibrutinib CAPSULE;ORAL 205552-002 Dec 20, 2017 RX Yes No ⤷  Free Forever Trial ⤷  Free Forever Trial TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA ⤷  Free Forever Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

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Boehringer Ingelheim
Mallinckrodt
Merck
Medtronic
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