Details for Patent: 8,487,129

Which drugs does patent 8,487,129 protect, and when does it expire?

Patent 8,487,129 protects PYLARIFY and PYLARIFY TRUVU and is included in two NDAs.

This patent has thirty-four patent family members in sixteen countries.

Summary for Patent: 8,487,129

Title:	Heterodimers of glutamic acid
Abstract:	Compounds of Formula (Ia) wherein R is a C6-C12 substituted or unsubstituted aryl, a C6-C12 substituted or unsubstituted heteroaryl, a C1-C6 substituted or unsubstituted alkyl or -NR'R', Q is C(O), O, NR', S, S(O)2, C(O)2 (CH2)p Y is C(O), O, NR', S, S(O)2, C(O)2 (CH2)p Z is H or C1-C4 alkyl, R' is H, C(O), S(O)2, C(O)2, a C6-C12 substituted or unsubstituted aryl, a C6-C12 substituted or unsubstituted heteroaryl or a C1-C6 substituted or unsubstituted alkyl, when substituted, aryl, heteroaryl and alkyl are substituted with halogen, C6-C12 heteroaryl, -NR'R' or COOZ, which have diagnostic and therapeutic properties, such as the treatment and management of prostate cancer and other diseases related to NAALADase inhibition. Radiolabels can be incorporated into the structure through a variety of prosthetic groups attached at the X amino acid side chain via a carbon or hetero atom linkage.
Inventor(s):	John W. Babich, Craig N. Zimmerman, Kevin P. Maresca
Assignee:	Molecular Insight Pharmaceuticals Inc
Application Number:	US13/294,677
Patent Claim Types: see list of patent claims	Compound;

Drugs Protected by US Patent 8,487,129

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
Progenics Pharms Inc	PYLARIFY	piflufolastat f-18	SOLUTION;INTRAVENOUS	214793-001	May 26, 2021		RX	Yes	Yes			Y	Y
Aphelion	PYLARIFY TRUVU	piflufolastat f-18	SOLUTION;INTRAVENOUS	220089-001	Mar 6, 2026		RX	Yes	Yes			Y	Y

International Family Members for US Patent 8,487,129

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Australia	2007316391
Brazil	PI0718700
Canada	2669127
China	101778910
China	103922998
Cyprus	1116610