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Serving leading biopharmaceutical companies globally:

Cerilliant
Fuji
Citi
Dow
Medtronic
Chinese Patent Office
Fish and Richardson
Argus Health
Moodys
Novartis

Generated: February 23, 2018

DrugPatentWatch Database Preview

Details for Patent: 8,481,526

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Which drugs does patent 8,481,526 protect, and when does it expire?

Patent 8,481,526 protects BESIVANCE and is included in one NDA.

This patent has eleven patent family members in ten countries.
Summary for Patent: 8,481,526
Title:Fluoroquinolone carboxylic acid molecular crystals
Abstract: Disclosed herein is a molecular crystal form of the compound (R)-(+)-7-(3-amino-2,3,4,5,6,7-hexahydro-1H-azepin-1-yl)-1-cyclopropyl-8-- chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid. The molecular crystal is characterized by at least one of: (a) an X-ray powder diffraction ("XRPD") spectrum that comprises peaks at 2.theta. angles of 10.6, 15, 19.7, 21.1, and 22.degree..+-.0.2.degree.; (b) a DSC melting peak at 288.degree. C.; (c) a .sup.13C NMR spectrum having peaks at 23.3, 27.7, 41.1, 54.5, 116.6, and 153.5 ppm; and (d) pKa values of 5.65 and 9.91. The compound belongs to the class of fluoroquinolones and is useful as an antibacterial agent.
Inventor(s): King, Jr.; Harry M. (Webster, NY)
Assignee: Bausch & Lomb Incorporated (Rochester, NY)
Application Number:12/723,047
Patent Claim Types:
see list of patent claims
Compound; Use; Formulation;

Drugs Protected by US Patent 8,481,526

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Bausch And Lomb BESIVANCE besifloxacin hydrochloride SUSPENSION/DROPS;OPHTHALMIC 022308-001 May 28, 2009 RX Yes Yes ➤ Sign Up ➤ Sign Up Y ➤ Sign Up
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Non-Orange Book US Patents Family Members for Patent 8,481,526

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
8,604,020 Fluoroquinolone carboxylic acid molecular crystals ➤ Sign Up
Patent No. Title Estimated Patent Expiration

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International Patents Family Members for US Patent 8,481,526

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Taiwan I468394 ➤ Sign Up
Taiwan 201038536 ➤ Sign Up
Mexico 2011009758 ➤ Sign Up
South Korea 20110122202 ➤ Sign Up
Japan 2012521433 ➤ Sign Up
European Patent Office 2411369 ➤ Sign Up
China 102369189 ➤ Sign Up
Canada 2756769 ➤ Sign Up
Brazil PI1009849 ➤ Sign Up
Argentina 075926 ➤ Sign Up
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Federal Trade Commission
McKesson
Cantor Fitzgerald
Cerilliant
Mallinckrodt
US Army
Daiichi Sankyo
Fish and Richardson
US Department of Justice

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