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Last Updated: October 16, 2019

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Details for Patent: 8,436,185

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Which drugs does patent 8,436,185 protect, and when does it expire?

Patent 8,436,185 protects ZEJULA and is included in one NDA.

This patent has twenty patent family members in fifteen countries.

Summary for Patent: 8,436,185
Title:Pharmaceutically acceptable salts of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide
Abstract: The present invention relates to pharmaceutically acceptable salts of an amide substituted indazole which are inhibitors of the enzyme poly(ADP-ribose)polymerase (PARP), previously known as poly(ADP-ribose)synthase and poly(ADP-ribosyl) transferase. The compounds of the present invention are useful as mono-therapies in tumors with specific defects in DNA-repair pathways and as enhancers of certain DNA-damaging agents such as anticancer agents and radiotherapy. Further, the compounds of the present invention are useful for reducing cell necrosis (in stroke and myocardial infarction), down regulating inflammation and tissue injury, treating retroviral infections and protecting against the toxicity of chemotherapy.
Inventor(s): Foley; Jennifer R. (Garwood, NJ), Wilson; Robert Darrin (Hoddesdon Herts, GB)
Assignee: Merck Sharp & Dohme Corp. (Rahway, NJ)
Application Number:12/811,922
Patent Claim Types:
see list of patent claims
Compound;

Drugs Protected by US Patent 8,436,185

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Tesaro Inc ZEJULA niraparib tosylate CAPSULE;ORAL 208447-001 Mar 27, 2017 RX Yes Yes   Request a Trial   Request a Trial Y   Request a Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 8,436,185

PCT Information
PCT FiledJanuary 08, 2009PCT Application Number:PCT/GB2009/000041
PCT Publication Date:July 16, 2009PCT Publication Number: WO2009/087381

International Family Members for US Patent 8,436,185

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Serving leading biopharmaceutical companies globally:

McKinsey
McKesson
AstraZeneca
Baxter
Boehringer Ingelheim
Mallinckrodt

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