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Last Updated: October 16, 2019

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Details for Patent: 8,404,724

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Summary for Patent: 8,404,724
Title:Unit dose formulations and methods of treating thrombosis with an oral factor Xa inhibitor
Abstract: Unit doses of factor Xa inhibitor compounds and methods of using these compounds for inhibiting blood coagulation in a human patient are taught herein. The unit dose of the factor Xa inhibitor compounds disclosed herein required to inhibit coagulation in a primate is lower than the unit dose required to obtain similar levels of coagulation inhibition in other animal models, such as rodents. Also taught are in vitro assays useful in predicting in vivo antithrombotic activity in humans.
Inventor(s): Sinha; Uma (San Francisco, CA), Hollenbach; Stanley J. (South San Francisco, CA), Abe; Keith (South San Francisco, CA)
Assignee: Millennium Pharmaceuticals, Inc. (Cambridge, MA)
Application Number:11/999,957
Patent Claim Types:
see list of patent claims
Use; Composition; Formulation; Compound;

Drugs Protected by US Patent 8,404,724

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Portola Pharms Inc BEVYXXA betrixaban CAPSULE;ORAL 208383-001 Jun 23, 2017 RX Yes No   Request a Trial   Request a Trial Y INHIBITING COAGULATION   Request a Trial
Portola Pharms Inc BEVYXXA betrixaban CAPSULE;ORAL 208383-002 Jun 23, 2017 RX Yes Yes   Request a Trial   Request a Trial Y INHIBITING COAGULATION   Request a Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

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