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Last Updated: October 18, 2019

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Details for Patent: 8,361,977

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Summary for Patent: 8,361,977
Title:Compositions and methods for modulation of SMN2 splicing
Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.
Inventor(s): Baker; Brenda F. (Carlsbad, CA), Krainer; Adrian R. (Huntington Station, NY), Hua; Yimin (Jericho, NY)
Assignee: Isis Pharmaceuticals, Inc. (Carlsbad, CA)
Application Number:11/993,609
Patent Claim Types:
see list of patent claims
Compound; Composition;

Drugs Protected by US Patent 8,361,977

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Biogen Idec SPINRAZA nusinersen sodium SOLUTION;INTRATHECAL 209531-001 Dec 23, 2016 RX Yes Yes   Start Trial   Start Trial Y Y   Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 8,361,977

PCT Information
PCT FiledJune 23, 2006PCT Application Number:PCT/US2006/024469
PCT Publication Date:January 04, 2007PCT Publication Number: WO2007/002390

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