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Details for Patent: 8,354,427

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Patent 8,354,427 protects KALYDECO and is included in two NDAs.

This patent has seventy-seven patent family members in nineteen countries.

Summary for Patent: 8,354,427

Title:Modulators of ATP-binding cassette transporters
Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
Inventor(s): Van Goor; Fredrick (San Diego, CA)
Assignee: Vertex Pharmaceutical Incorporated (Cambridge, MA)
Application Number:12/635,927
Patent Claim Types:
see list of patent claims
Use;
Patent Metrics:
Source: PatentQuant.com
Field: Pharmaceuticals
Back Citations: 0th percentile
Forward Citations: 29th percentile

Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Vertex Pharms Inc
KALYDECO
ivacaftor
GRANULE;ORAL207925-001Mar 17, 2015RXNo8,354,427► subscribe METHOD OF TREATING CYSTIC FIBROSIS
Vertex Pharms Inc
KALYDECO
ivacaftor
GRANULE;ORAL207925-001Mar 17, 2015RXNo8,354,427► subscribe
Vertex Pharms Inc
KALYDECO
ivacaftor
GRANULE;ORAL207925-002Mar 17, 2015RXYes8,354,427► subscribe METHOD OF TREATING CYSTIC FIBROSIS
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Non-Orange Book Patents for Patent: 8,354,427

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
8,829,204Modulators of ATP-binding cassette transporters► subscribe
8,614,327Modulators of ATP-binding cassette transporters► subscribe
9,090,619Modulators of ATP-binding cassette transporters► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Because of the complexity of determining patent expiration dates it is advisable to have patent counsel verify freedom to operate.

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International Patent Family for Patent: 8,354,427

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Australia2005258320► subscribe
Australia2010249302► subscribe
Australia2010251787► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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