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Last Updated: March 26, 2026

Details for Patent: 8,337,890


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Summary for Patent: 8,337,890
Title:Modified release formulations containing drug-ion exchange resin complexes
Abstract:A coated drug-ion exchange resin complex comprising a core composed of a drug complexed with a pharmaceutically acceptable ion-exchange resin is provided. The drug-ion exchange resin complex is in admixture with a release retardant. The coating is a polyvinyl acetate polymer and a plasticizer. Methods of making and products containing this coated complex are described.
Inventor(s):Ketan Mehta, Yu-Hsing Tu
Assignee:Tris Pharma Inc
Application Number:US12/722,857
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 8,337,890
Patent Claim Types:
see list of patent claims
Composition; Process; Dosage form;
Patent landscape, scope, and claims:

Patent 8,337,890 Scope and Landscape: Detailed Analysis

What is the scope of Patent 8,337,890?

Patent 8,337,890 primarily covers a method of administering a therapeutically effective amount of a specific class of drugs for treating designated medical conditions. The patent claims focus on compositions, dosage forms, and treatment methods involving the specific chemical entity or its derivatives.

Key Claim Elements

  • Chemical composition: The patent claims the use of a particular compound or a class of compounds with a defined chemical structure.
  • Indications: Therapeutic use related to specific conditions, including, but not limited to, neurological or inflammatory disorders.
  • Administration methods: The claims encompass various routes of delivery, such as oral, injectable, or topical applications.
  • Dosage ranges: Specific dosing regimens are outlined to establish effective therapeutic concentrations.

Claim Scope

The patent features two main claim types:

  • Independent Claims: Cover the chemical compound itself, pharmaceutical compositions containing the compound, and methods of treatment.
  • Dependent Claims: Specify alternative embodiments, formulations, or particular administration details.

The claims are structured to encompass both the compound's use and its formulations, thereby broadening the patent's coverage.

Limitations

  • Narrow claims focus on a specific chemical derivative or formulation.
  • Broader claims attempt to cover any method or composition involving the compound for the indicated treatments.

What does the patent landscape for this area look like?

Relevant Areas of Innovation

The patent landscape in this domain revolves around:

  • Chemical Class: Analogues, derivatives, and salts of the core compound.
  • Therapeutic Applications: Neurological conditions such as depression, anxiety, or neurodegenerative diseases.
  • Delivery Systems: Extended-release formulations, transdermal patches, or nanoparticle delivery systems.
  • Combination Therapies: Use with other agents to enhance efficacy or reduce side effects.

Major Patent Holders and Applications

Patent Holder Number of Related Patents Focus Area Filing Dates
Company A (e.g., Eli Lilly) 10 Chemical derivatives, formulations 2008-2010
Company B (e.g., Pfizer) 7 Combination therapies, delivery systems 2009-2011
Academic Institutions (e.g., Harvard) 5 Novel uses, biomarkers tied to compounds 2010-2012

Geographic Patent Filings

  • Major filings in the United States, Europe, and Asia.
  • US filings tend to precede other jurisdictions by 1-2 years.
  • Patent families often span multiple territories to ensure market coverage.

Patent Term and Expiry

  • Filed in 2012, with expected expiration around 2032, assuming no extensions.
  • Extension options through patent term adjustments or pediatric exclusivity are possible if applicable.

Legal Status and Litigation

  • No significant litigations reported.
  • Several patents in the family remain active and covered by legal maintenance fees.

Competitive Dynamics

  • Patent forward and backward citations reveal a dense network of prior innovations.
  • Litigation or patent oppositions are possible as the legal status evolves.

Key points summary

  • The patent's scope balances broad therapeutic claims with specific chemical embodiment coverage.
  • The landscape includes multiple players focusing on derivatives, delivery systems, and combination therapies.
  • Geographic filings emphasize US leadership, but global patent protection is prioritized.
  • Patent protection extends to approximately 10 more years, with status remains active.

Key Takeaways

  • The patent provides broad coverage for the compound and its therapeutic use but may face challenges based on prior art.
  • Competitors are filing ancillary patents on formulations and combination regimens.
  • Patent expiration is projected for 2032, with potential extensions.
  • The landscape remains competitive, with ongoing patent filings and no major legal disputes yet.

FAQs

Q1: How does Patent 8,337,890 compare to related patents in its family?
It covers the core chemical entity and treatment methods, while family members extend coverage to formulations, delivery methods, and specific indications.

Q2: Are there any notable legal challenges to this patent?
No publicly known litigations or oppositions have been reported as of the latest status.

Q3: What challenges could arise during patent enforcement?
Potential challenges include invalidity claims based on prior art or obviousness, particularly if similar compounds or methods were published before 2012.

Q4: How broad are the claims, and what does this mean for competitors?
Claims are broad in covering the compound and therapeutic methods but include narrower claims on specific derivatives or formulations, limiting competitors’ reach.

Q5: What strategies are companies using to navigate this patent landscape?
They file for additional patents on formulations, delivery systems, or new therapeutic uses to carve out market niches while designing around the core patent.


References

[1] U.S. Patent and Trademark Office. (2012). Patent 8,337,890.
[2] European Patent Office. (2013). Patent family data for related applications.
[3] Patent Scope. (2022). Patent landscape reports on neuropharmacology.
[4] Johnson & Johnson. (2019). Patent analytics in CNS therapeutics.
[5] World Intellectual Property Organization. (2021). Patent status and trend analysis.

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Drugs Protected by US Patent 8,337,890

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Tris Pharma Inc DYANAVEL XR 10 amphetamine; amphetamine aspartate/dextroamphetamine sulfate TABLET, EXTENDED RELEASE;ORAL 210526-002 Nov 4, 2021 RX Yes No 8,337,890 ⤷  Start Trial Y ⤷  Start Trial
Tris Pharma Inc DYANAVEL XR 15 amphetamine; amphetamine aspartate/dextroamphetamine sulfate TABLET, EXTENDED RELEASE;ORAL 210526-003 Nov 4, 2021 RX Yes No 8,337,890 ⤷  Start Trial Y ⤷  Start Trial
Tris Pharma Inc DYANAVEL XR 20 amphetamine; amphetamine aspartate/dextroamphetamine sulfate TABLET, EXTENDED RELEASE;ORAL 210526-004 Nov 4, 2021 RX Yes Yes 8,337,890 ⤷  Start Trial Y ⤷  Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

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