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AstraZeneca
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Generated: December 12, 2017

DrugPatentWatch Database Preview

Details for Patent: 8,334,270

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Which drugs does patent 8,334,270 protect, and when does it expire?


Patent 8,334,270 protects EPCLUSA, HARVONI, SOVALDI, and VOSEVI, and is included in four NDAs.

This patent has fifty-nine patent family members in thirty-three countries.

Summary for Patent: 8,334,270

Title:Nucleoside phosphoramidate prodrugs
Abstract: Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: ##STR00001## Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.
Inventor(s): Sofia; Michael Joseph (Doylestown, PA), Du; Jinfa (New Hope, PA), Wang; Peiyuan (Glen Rock, NJ), Nagarathnam; Dhanapalan (Bethany, CT)
Assignee: Gilead Pharmasset LLC (Foster City, CA)
Application Number:13/099,671
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Patent Submitted Product Substance Delist Req. Patented / Exclusive Use
Gilead Sciences IncEPCLUSAsofosbuvir; velpatasvirTABLET;ORAL208341-001Jun 28, 2016RXYesYes► Subscribe► Subscribe► SubscribeYYFOR THE TREATMENT OF HEPATITIS C
Gilead Sciences IncHARVONIledipasvir; sofosbuvirTABLET;ORAL205834-001Oct 10, 2014RXYesYes► Subscribe► Subscribe► SubscribeYYFOR THE TREATMENT OF HEPATITIS C
Gilead Sciences IncSOVALDIsofosbuvirTABLET;ORAL204671-001Dec 6, 2013RXYesYes► Subscribe► Subscribe► SubscribeYYFOR THE TREATMENT OF HEPATITIS C
Gilead Sciences IncVOSEVIsofosbuvir; velpatasvir; voxilaprevirTABLET;ORAL209195-001Jul 18, 2017RXYesYes► Subscribe► Subscribe► SubscribeYY
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Non-Orange Book Patents for Patent: 8,334,270

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
9,585,906Nucleoside phosphoramidate prodrugs► Subscribe
7,964,580Nucleoside phosphoramidate prodrugs► Subscribe
9,085,573Nucleoside phosphoramidate prodrugs► Subscribe
8,906,880Nucleoside phosphoramidate prodrugs► Subscribe
8,957,046Nucleoside phosphoramidate prodrugs► Subscribe
8,735,372Nucleoside phosphoramidate prodrugs► Subscribe
8,580,765Nucleoside phosphoramidate prodrugs► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Because of the complexity of determining patent expiration dates it is advisable to have patent counsel verify freedom to operate.

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International Patent Family for Patent: 8,334,270

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
TaiwanI357332► Subscribe
Taiwan200904453► Subscribe
Slovenia2203462► Subscribe
Singapore2014011704► Subscribe
Singapore179445► Subscribe
Russian Federation2012152811► Subscribe
Russian Federation2478104► Subscribe
Russian Federation2009139968► Subscribe
Portugal2203462► Subscribe
Philippines12014502771► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Argus Health
Colorcon
Medtronic
Teva
Express Scripts
US Department of Justice
AstraZeneca
Fuji
Farmers Insurance
Novartis

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

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