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Serving leading biopharmaceutical companies globally:

Healthtrust
Express Scripts
AstraZeneca
Fish and Richardson
Teva
Argus Health
Novartis
Baxter
Cipla
Cantor Fitzgerald

Generated: January 18, 2018

DrugPatentWatch Database Preview

Details for Patent: 8,207,297

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Which drugs does patent 8,207,297 protect, and when does it expire?

Patent 8,207,297 protects KYPROLIS and is included in one NDA.

This patent has sixty-nine patent family members in twenty-four countries.
Summary for Patent: 8,207,297
Title:Compounds for enzyme inhibition
Abstract: Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation.
Inventor(s): Smyth; Mark S. (Foster City, CA), Laidig; Guy J. (Menlo Park, CA)
Assignee: Onyx Therapeutics, Inc. (South San Francisco, CA)
Application Number:13/334,469
Patent Claim Types:
see list of patent claims
Use; Process; Composition; Formulation; Dosage form; Compound;

Drugs Protected by US Patent 8,207,297

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Onyx Therap KYPROLIS carfilzomib POWDER;INTRAVENOUS 202714-002 Jun 3, 2016 RX Yes No ➤ Subscribe ➤ Subscribe Y Y ➤ Subscribe
Onyx Therap KYPROLIS carfilzomib POWDER;INTRAVENOUS 202714-001 Jul 20, 2012 RX Yes Yes ➤ Subscribe ➤ Subscribe Y Y ➤ Subscribe
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Non-Orange Book US Patents Family Members for Patent 8,207,297

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
8,198,270 Compounds for proteasome enzyme inhibition ➤ Subscribe
7,232,818 Compounds for enzyme inhibition ➤ Subscribe
8,207,126 Compounds for enzyme inhibition ➤ Subscribe
7,417,042 Compounds for enzyme inhibition ➤ Subscribe
8,207,124 Compounds for enzyme inhibition ➤ Subscribe
8,129,346 Compounds for enzyme inhibition ➤ Subscribe
7,491,704 Compounds for enzyme inhibition ➤ Subscribe
8,324,174 Compounds for enzyme inhibition ➤ Subscribe
8,207,125 Compounds for enzyme inhibition ➤ Subscribe
8,207,127 Compounds for enzyme inhibition ➤ Subscribe
Patent No. Title Estimated Patent Expiration

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International Patents Family Members for US Patent 8,207,297

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Spain 2359004 ➤ Subscribe
Spain 2525248 ➤ Subscribe
Spain 2358268 ➤ Subscribe
European Patent Office 2266999 ➤ Subscribe
Hungary S1600014 ➤ Subscribe
Hong Kong 1152716 ➤ Subscribe
Hong Kong 1097860 ➤ Subscribe
Hong Kong 1103525 ➤ Subscribe
Israel 178400 ➤ Subscribe
Hong Kong 1152536 ➤ Subscribe
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving leading biopharmaceutical companies globally:

Federal Trade Commission
Express Scripts
Chubb
Healthtrust
Deloitte
Fish and Richardson
Boehringer Ingelheim
Medtronic
Dow

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

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