Details for Patent: 8,207,297

Which drugs does patent 8,207,297 protect, and when does it expire?

Patent 8,207,297 protects KYPROLIS and is included in one NDA.

This patent has ninety patent family members in twenty-six countries.

Summary for Patent: 8,207,297

Title:	Compounds for enzyme inhibition
Abstract:	Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation.
Inventor(s):	Smyth; Mark S. (Foster City, CA), Laidig; Guy J. (Menlo Park, CA)
Assignee:	Onyx Therapeutics, Inc. (South San Francisco, CA)
Application Number:	13/334,469
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 8,207,297
Patent Claim Types: see list of patent claims	Use; Process; Composition; Formulation; Dosage form; Compound;

Drugs Protected by US Patent 8,207,297

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
Onyx Therap	KYPROLIS	carfilzomib	POWDER;INTRAVENOUS	202714-003	Jun 7, 2018		RX	Yes	No			Y	Y
Onyx Therap	KYPROLIS	carfilzomib	POWDER;INTRAVENOUS	202714-002	Jun 3, 2016		RX	Yes	No			Y	Y
Onyx Therap	KYPROLIS	carfilzomib	POWDER;INTRAVENOUS	202714-001	Jul 20, 2012	AP	RX	Yes	Yes			Y	Y

International Family Members for US Patent 8,207,297

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Austria	494298
Austria	496062
Australia	2005238445
Australia	2005271232
Australia	2005295183