Details for Patent: 8,207,127
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Summary for Patent: 8,207,127
| Title: | Compounds for enzyme inhibition |
| Abstract: | Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation. |
| Inventor(s): | Mark S. Smyth, Guy J. Laidig |
| Assignee: | Onyx Technologies USA Inc , Onyx Therapeutics Inc |
| Application Number: | US13/334,544 |
| Patent Litigation and PTAB cases: | See patent lawsuits and PTAB cases for patent 8,207,127 |
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Patent Claim Types: see list of patent claims | Use; Composition; Formulation; Device; Dosage form; |
Drugs Protected by US Patent 8,207,127
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| >Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
International Family Members for US Patent 8,207,127
| Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
|---|---|---|---|---|---|
| European Patent Office | 1781688 | ⤷ Start Trial | PA2016010 | Lithuania | ⤷ Start Trial |
| European Patent Office | 1781688 | ⤷ Start Trial | 93015 | Luxembourg | ⤷ Start Trial |
| European Patent Office | 1781688 | ⤷ Start Trial | CA 2016 00014 | Denmark | ⤷ Start Trial |
| European Patent Office | 1781688 | ⤷ Start Trial | 300805 | Netherlands | ⤷ Start Trial |
| European Patent Office | 1781688 | ⤷ Start Trial | 16C0017 | France | ⤷ Start Trial |
| European Patent Office | 1781688 | ⤷ Start Trial | C20160008 00189 | Estonia | ⤷ Start Trial |
| European Patent Office | 1781688 | ⤷ Start Trial | 1690013-6 | Sweden | ⤷ Start Trial |
| >Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |
