Last Updated: November 9, 2026

Details for Patent: 8,193,229

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Summary for Patent: 8,193,229
Title:Method of treatment using N3 alkylated benzimidazole derivatives as MEK inhibitors
Abstract:Disclosed are methods of treating a hyperproliferative disorder or a disease related to vasculogenesis or angiogenesis in a mammal, comprising administering to said mammal an effective amount of a compound of the formula or a pharmaceutically accepted salt thereof, wherein A, R1, R2, R7, R8, and R9 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals.
Inventor(s):Eli M. Wallace, Joseph P. Lyssikatos, Allison L. Marlow, T. Brian Hurley
Assignee: AstraZeneca AB , Array Biopharma Inc
Application Number:US12/824,521
Patent Claim Types:
see list of patent claims
Use;

Drugs Protected by US Patent 8,193,229

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 8,193,229

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office 1482932 ⤷  Start Trial PA2019007 Lithuania ⤷  Start Trial
European Patent Office 1482932 ⤷  Start Trial LUC00100 Luxembourg ⤷  Start Trial
European Patent Office 1482932 ⤷  Start Trial 300974 Netherlands ⤷  Start Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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