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Last Updated: October 21, 2019

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Details for Patent: 8,133,893

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Summary for Patent: 8,133,893
Title:Trazodone and trazodone hydrochloride in purified form
Abstract: A process of production of trazodone or trazodone hydrochloride that comprises the steps of: (a) preparing an organic phase comprising trazodone in at least one organic solvent; (b) preparing an aqueous phase comprising at least one basic compound; (c) mixing said aqueous phase with said organic phase; (d) heating at a temperature of at least 40.degree. C. for at least 30 minutes; (e) recovering said trazodone; and, optionally, (f) treating said trazodone with hydrochloric acid to obtain trazodone hydrochloride. Trazodone or trazodone hydrochloride comprising less than 15 ppm of alkylating substances, and a pharmaceutical composition comprising said trazodone hydrochloride. ##STR00001##
Inventor(s): Marchetti; Marcello (Rome, IT), Iacoangeli; Tommaso (Rome, IT), Ciottoli; Giovanni Battista (Rome, IT), Biondi; Giuseppe (Castel Gandolfo, IT)
Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A. (Rome, IT)
Application Number:12/513,048
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 8,133,893
Patent Claim Types:
see list of patent claims
Compound; Composition; Use; Process;

Drugs Protected by US Patent 8,133,893

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Angelini Pharma OLEPTRO trazodone hydrochloride TABLET, EXTENDED RELEASE;ORAL 022411-001 Feb 2, 2010 DISCN Yes No   Start Trial   Start Trial Y Y   Start Trial
Angelini Pharma OLEPTRO trazodone hydrochloride TABLET, EXTENDED RELEASE;ORAL 022411-002 Feb 2, 2010 DISCN Yes No   Start Trial   Start Trial Y Y   Start Trial
Pragma DESYREL trazodone hydrochloride TABLET;ORAL 018207-001 Approved Prior to Jan 1, 1982 DISCN Yes No   Start Trial   Start Trial Y Y   Start Trial
Pragma DESYREL trazodone hydrochloride TABLET;ORAL 018207-002 Approved Prior to Jan 1, 1982 DISCN Yes No   Start Trial   Start Trial Y Y   Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 8,133,893

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
ItalyMI2007A1603Aug 03, 2007
PCT Information
PCT FiledJuly 23, 2008PCT Application Number:PCT/EP2008/059640
PCT Publication Date:February 12, 2009PCT Publication Number: WO2009/019133

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