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Details for Patent: 8,058,238

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Summary for Patent: 8,058,238

Title:High purity lipopeptides
Abstract: The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography. The invention also discloses a method of purifying daptomycin by modified buffer enhanced anion exchange chromatography. The invention also discloses an improved method for producing daptomycin by fermentation of Streptomyces roseosporus. The invention also discloses high pressure liquid chromatography methods for analysis of daptomycin purity. The invention also discloses lipopeptide micelles and methods of making the micelles. The invention also discloses methods of using lipopeptide micelles for purifying lipopeptide antibiotics, such as daptomycin. The invention also discloses using lipopeptide micelles therapeutically.
Inventor(s): Kelleher; Thomas (Weston, MA), Lai; Jan-Ji (Westborough, MA), DeCourcey; Joseph P. (Charlestown, MA), Lynch; Paul (Arlington, MA), Zenoni; Maurizio (Milan, IT), Tagliani; Auro (Pavia, IT)
Assignee: Cubist Pharmaceuticals, Inc. (Lexington, MA)
Application Number:11/739,180
Patent Claim Types:
see list of patent claims
Composition; Process; Formulation; Use;
Patent Metrics:
Source: PatentQuant.com
Field: Biotechnology
Back Citations: 28th percentile
Forward Citations: 8th percentile

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International Patent Family for Patent: 8,058,238

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria311405► subscribe
Austria449785► subscribe
Australia3097801► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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