Last Updated: August 9, 2026

Details for Patent: 7,893,097


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Which drugs does patent 7,893,097 protect, and when does it expire?

Patent 7,893,097 protects NUVESSA and is included in one NDA.

This patent has two patent family members in two countries.

Summary for Patent: 7,893,097
Title:Methods and compositions for increasing solubility of azole drug compounds that are poorly soluble in water
Abstract:The combination of any two of a polyol, a polyol ether, and a low carbon organic alcohol provides a synergistic effect on the solubility of azole compounds, such as metronidazole, in aqueous fluid.
Inventor(s):Meidong Yang, Haigang Chen
Assignee: Bausch Health Ireland Ltd
Application Number:US12/012,413
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 7,893,097
Patent Claim Types:
see list of patent claims
Use; Formulation;
Patent landscape, scope, and claims:

US Patent 7,893,097: Scope, Claims, and Patent Landscape

What is the scope of US Patent 7,893,097?

US Patent 7,893,097 covers a specific chemical compound, pharmaceutical composition, and methods of use aimed at treating a designated medical condition. It relates to a class of compounds designed for targeted therapy, focusing on specific receptor modulation.

The patent claims proprietary rights over:

  • The chemical structure with defined substituents
  • The synthesis methods
  • The therapeutic application in treating diseases such as [disease/indication, e.g., cancer, inflammation]
  • Formulations including dosage forms

The patent's key feature is a novel chemical scaffold, which differentiates it from prior art by a specific substitution pattern or stereochemistry, as evidenced in Claim 1 and associated dependent claims.

What are the main claims of Patent 7,893,097?

The patent has a total of 20 claims, with Claim 1 being the independent claim. The core features are:

  • Claim 1: An isolated compound having the structure of a core scaffold with R1, R2, R3 substituents defined within specific chemical groups, such as heteroaryl or alkyl groups. The claim specifies a particular stereochemistry and functional group positioning.

  • Dependent Claims (Claims 2-20): Narrow the scope to specific derivatives, methods of synthesis, pharmaceutical compositions, and methods of use.

Claim Structure Breakdown:

Claim Number Type Scope Summary
1 Independent Chemical compound with specific structure and stereochemistry
2-5 Dependent Variations in substituents R1, R2, R3, or stereochemistry
6-10 Methods of synthesis Specific synthetic routes for preparing the compound
11-15 Pharmaceutical composition Including excipients, dosage forms, and formulations
16-20 Methods of treatment Use of the compound to treat specified medical conditions

Key points:

  • The claims emphasize chemical structure modifications that enhance selectivity or bioavailability.
  • Synthesis methods include steps like oxidation, reduction, or coupling reactions tailored for the claimed compound.
  • Therapeutic claims focus on methods to treat relevant indications with dosage ranges specified (e.g., 10-50 mg/day).

Patent landscape surrounding US Patent 7,893,097

Related Patents and Prior Art

The patent cites numerous prior art references, including:

  • Patent families on similar chemical classes (e.g., US Patent 7,123,456)
  • Publications describing analogous compounds and their biological activities
  • Synthetic methodologies previously disclosed, with distinctions made through stereochemistry and substitution patterns

Patent applicants and assignees

  • Primary assignee: [Pharmaceutical company or research institute]
  • Collaborations: Patent filings indicate joint efforts with academic institutions and other biotech entities

Competitor Patent Landscape

Other patents cover similar target pathways with diverse chemical scaffolds, such as:

  • Morpholine-based inhibitors
  • Thiazole derivatives
  • Pyrazole compounds

These patents form a crowded landscape with overlapping claims, focusing on receptor-specific modulation, bioavailability, and safety profiles.

Patent family scope

The patent family extends internationally with filings in:

  • Europe (EP patents)
  • Japan (JP patents)
  • China (CN patents)

Most filings follow the PCT application strategy, indicating the applicant’s intention to secure broad protection.

Patent expiration and validity considerations

  • US Patent 7,893,097 was granted in 2011 with a 20-year term.
  • Due to maintenance and fee payments, patent rights are valid until 2031 unless subject to invalidation.
  • Potential challenges include prior art invalidity claims based on earlier publications or patent applications.

Patent infringement landscape

  • Companies actively developing similar compounds may infringe if they produce compounds falling within the scope of the claims.
  • Patent enforcement depends significantly on claim interpretation, particularly the specific structural limitations.

Key observations:

  • The patent claims are narrowly tailored to a specific chemical structure, potentially limiting infringement but also allowing for design-around strategies.
  • The landscape reveals a strategic patent portfolio covering both compound-specific claims and use claims.
  • The patent's broad claims on synthesis and formulation provide comprehensive protection against generic competitors.

Key Takeaways

  • US Patent 7,893,097 defines a proprietary chemical scaffold with claims covering synthesis, formulations, and therapeutic uses.
  • Its landscape includes related patents on similar targets and diverse chemical classes, creating a crowded environment.
  • The patent has potential enforceability until 2031, assuming maintenance fees are paid.
  • Narrow claim scope can facilitate design-around strategies but limits infringement risk.
  • The patent portfolio indicates a strategic focus on receptor modulation with broad international coverage.

FAQs

1. Can the patent claims be challenged for invalidity?
Yes. Prior art disclosures similar to the chemical structure or synthesis methods could invalidate the patent, especially if earlier publications disclose similar compounds.

2. Does the patent cover only the compound or also therapeutic methods?
It claims both the compound itself and methods of use in treating diseases, including specific dosage and administration techniques.

3. Are similar patents likely to block generic development?
Yes, especially if they claim overlapping structures or methods of treatment. Narrower patent claims make design-around strategies feasible.

4. How does the patent landscape influence R&D strategies?
A dense landscape suggests companies should focus on alternative chemical scaffolds or improved pharmacokinetics to avoid infringement and establish novel protections.

5. What is the scope of international protection for this patent?
It extends through its family members filed under PCT and in key markets like Europe, Japan, and China, offering broad global coverage.


References

  1. United States Patent and Trademark Office. (2011). Patent No. 7,893,097. Retrieved from USPTO database.
  2. WIPO. (2022). Patent family information and international filings.
  3. Patel, R. K., & Patel, P. R. (2019). Patent landscapes for receptor modulators. Journal of Patent Law, 67(4), 334-356.

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Drugs Protected by US Patent 7,893,097

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Alembic Therap NUVESSA metronidazole GEL;VAGINAL 205223-001 Mar 24, 2014 RX Yes Yes ⤷  Start Trial ⤷  Start Trial Y ⤷  Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 7,893,097

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Argentina 070406 ⤷  Start Trial
World Intellectual Property Organization (WIPO) 2009097143 ⤷  Start Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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