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Generated: May 26, 2019

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Details for Patent: 7,799,897

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Summary for Patent: 7,799,897
Title:Guanylate cyclase receptor agonists for the treatment of tissue inflammation and carcinogenesis
Abstract: A method of treatment of inflamed, pre-cancerous or cancerous tissue or polyps in a mammalian subject is disclosed. The treatment involves administration of a composition of at least one peptide agonist of a guanylate cyclase receptor and/or other small molecules that enhance intracellular production of cGMP. The at least one peptide agonist of a guanylate cyclase receptor may be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The inhibitor may be a small molecule, peptide, protein or other compound that inhibits the degradation of cGMP. Without requiring a particular mechanism of action, this treatment may restore a healthy balance between proliferation and apoptosis in the subject's population of epithelial cells, and also suppress carcinogenesis. Thus, the method may be used to treat, inter alia, inflammation, including gastrointestinal inflammatory disorders, general organ inflammation and asthma, and carcinogenesis of the lung, gastrointestinal tract, bladder, testis, prostate and pancreas, or polyps.
Inventor(s): Jacob; Gary S. (NY, NY), Nikiforovich; Gregory (St. Louis, MO), Shailubhai; Kunwar (Audubon, PA)
Assignee: Synergy Pharmaceuticals, Inc. (New York, NY)
Application Number:11/347,115
Prior Art and Litigation SupportOrder Prior Art and Litigation support for Patent 7,799,897
Patent Claim Types:
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Composition; Formulation; Dosage form;

Drugs Protected by US Patent 7,799,897

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Synergy Pharms TRULANCE plecanatide TABLET;ORAL 208745-001 Jan 19, 2017 RX Yes Yes ➤ Sign Up ➤ Sign Up Y ➤ Sign Up
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate

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