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Serving leading biopharmaceutical companies globally:

Chubb
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Queensland Health
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Fish and Richardson
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Argus Health
Harvard Business School
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Generated: December 16, 2017

DrugPatentWatch Database Preview

Details for Patent: 7,659,253

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Which drugs does patent 7,659,253 protect, and when does it expire?


Patent 7,659,253 protects VYVANSE and is included in two NDAs. There has been one Paragraph IV challenge on Vyvanse.

This patent has one hundred and forty-three patent family members in twenty-six countries.

Summary for Patent: 7,659,253

Title:Abuse-resistant amphetamine prodrugs
Abstract:The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.
Inventor(s): Mickle; Travis (Coralville, IA), Krishnan; Suma (Belvedere, CA), Bishop; Barney (Annandale, VA), Lauderback; Christopher (Blacksburg, VA), Moncrief; James Scott (Christiansburg, VA), Oberlender; Robert (Blacksburg, VA), Piccariello; Thomas (Blacksburg, VA), Paul; Bernhard J. (Lexington, MA), Verbicky; Christopher A. (Broadalbin, NY)
Assignee: Shire LLC (Florence, KY)
Application Number:12/131,923
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Shire DevelopmentVYVANSElisdexamfetamine dimesylateCAPSULE;ORAL021977-007Oct 30, 2014RXYesNo► Subscribe► SubscribeYYFOR THE TREATMENT OF ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)► Subscribe
Shire DevelopmentVYVANSElisdexamfetamine dimesylateCAPSULE;ORAL021977-004Dec 10, 2007RXYesNo► Subscribe► SubscribeYYFOR THE TREATMENT OF ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)► Subscribe
Shire DevelopmentVYVANSElisdexamfetamine dimesylateCAPSULE;ORAL021977-001Feb 23, 2007RXYesNo► Subscribe► SubscribeYYFOR THE TREATMENT OF ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)► Subscribe
Shire DevelopmentVYVANSElisdexamfetamine dimesylateCAPSULE;ORAL021977-005Dec 10, 2007RXYesNo► Subscribe► SubscribeYYFOR THE TREATMENT OF ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)► Subscribe
Shire DevelopmentVYVANSElisdexamfetamine dimesylateCAPSULE;ORAL021977-002Feb 23, 2007RXYesNo► Subscribe► SubscribeYYFOR THE TREATMENT OF ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)► Subscribe
Shire DevelopmentVYVANSElisdexamfetamine dimesylateCAPSULE;ORAL021977-006Dec 10, 2007RXYesNo► Subscribe► SubscribeYYFOR THE TREATMENT OF ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)► Subscribe
Shire DevelopmentVYVANSElisdexamfetamine dimesylateCAPSULE;ORAL021977-003Feb 23, 2007RXYesYes► Subscribe► SubscribeYYFOR THE TREATMENT OF ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)► Subscribe
Shire Dev LlcVYVANSElisdexamfetamine dimesylateTABLET, CHEWABLE;ORAL208510-001Jan 28, 2017RXYesNo► Subscribe► SubscribeYYFOR THE TREATMENT OF ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)► Subscribe
Shire Dev LlcVYVANSElisdexamfetamine dimesylateTABLET, CHEWABLE;ORAL208510-002Jan 28, 2017RXYesNo► Subscribe► SubscribeYYFOR THE TREATMENT OF ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)► Subscribe
Shire Dev LlcVYVANSElisdexamfetamine dimesylateTABLET, CHEWABLE;ORAL208510-003Jan 28, 2017RXYesNo► Subscribe► SubscribeYYFOR THE TREATMENT OF ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)► Subscribe
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Non-Orange Book Patents for Patent: 7,659,253

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
7,674,774Abuse-resistant amphetamine prodrugs► Subscribe
7,671,030Abuse-resistant amphetamine prodrugs► Subscribe
7,223,735Abuse resistant lysine amphetamine compounds► Subscribe
7,678,771Abuse-resistant amphetamine prodrugs► Subscribe
7,662,787Abuse resistant lysine amphetamine compounds► Subscribe
7,622,441Sustained release pharmaceutical compounds to prevent abuse of controlled substances► Subscribe
6,716,452 Active agent delivery systems and methods for protecting and administering active agents► Subscribe
7,687,467Abuse-resistant amphetamine prodrugs► Subscribe
7,713,936Abuse-resistant amphetamine prodrugs► Subscribe
7,338,939Abuse-resistant hydrocodone compounds► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Because of the complexity of determining patent expiration dates it is advisable to have patent counsel verify freedom to operate.

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International Patent Family for Patent: 7,659,253

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
World Intellectual Property Organization (WIPO)03034980► Subscribe
World Intellectual Property Organization (WIPO)03020200► Subscribe
World Intellectual Property Organization (WIPO)02051432► Subscribe
World Intellectual Property Organization (WIPO)0234237► Subscribe
World Intellectual Property Organization (WIPO)0053233► Subscribe
World Intellectual Property Organization (WIPO)0052078► Subscribe
Slovenia1644019► Subscribe
Singapore147485► Subscribe
Russian Federation2445085► Subscribe
Russian Federation2007136824► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

UBS
Teva
Mallinckrodt
Johnson and Johnson
Fish and Richardson
Accenture
Chubb
Cipla
Merck
Moodys

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

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