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Details for Patent: 7,491,725

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Patent 7,491,725 protects SPRYCEL and is included in one NDA. There have been two Paragraph IV challenges on Sprycel.

This patent has forty patent family members in twenty-seven countries.

Summary for Patent: 7,491,725

Title:Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
Abstract:The invention relates to processes for preparing compounds having the formula, ##STR00001## and crystalline forms thereof, wherein Ar is aryl or heteroaryl, L is an optional alkylene linker, and R.sub.2, R.sub.3, R.sub.4, and R.sub.5, are as defined in the specification herein, which compounds are useful as kinase inhibitors, in particular, inhibitors of protein tyrosine kinase and p38 kinase.
Inventor(s): Lajeunesse; Jean (Candiac, CA), DiMarco; John D. (East Brunswick, NJ), Galella; Michael (Kendall Park, NJ), Chidambaram; Ramakrishnan (Pennington, NJ)
Assignee: Bristol-Myers Squibb Company (Princeton, NJ)
Application Number:11/192,867
Patent Claim Types:
see list of patent claims
Compound; Composition; Process;
Patent Metrics:
Source: PatentQuant.com
Field: Pharmaceuticals
Back Citations: 9th percentile
Forward Citations: 4th percentile

Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Bristol Myers Squibb
SPRYCEL
dasatinib
TABLET;ORAL021986-001Jun 28, 2006RXNo7,491,725► subscribeYY
Bristol Myers Squibb
SPRYCEL
dasatinib
TABLET;ORAL021986-002Jun 28, 2006RXNo7,491,725► subscribeYY
Bristol Myers Squibb
SPRYCEL
dasatinib
TABLET;ORAL021986-003Jun 28, 2006RXNo7,491,725► subscribeYY
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Non-Orange Book Patents for Patent: 7,491,725

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
8,680,103Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors► subscribe
8,242,270Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Because of the complexity of determining patent expiration dates it is advisable to have patent counsel verify freedom to operate.

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International Patent Family for Patent: 7,491,725

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Argentina047533► subscribe
Argentina053984► subscribe
Austria453630► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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