Zinc-free and low-zinc insulin preparations having improved stability
The invention relates to a formulation comprising a polypeptide selected from at least one of insulin, an insulin metabolite, an insulin analog, and an insulin derivative; at least one surfactant; optionally at least one preservative; and optionally at least one of an isotonicizing agent, a buffer or an excipient, wherein the formulation is free from or low in zinc. The invention also relates to the production of such insulin preparations and their use as pharmaceutical formulations.
Boderke; Peter (Frankfurt am Main, DE)
Sanofi-Aventis Deutschland GmbH (Frankfurt am Main, DE)
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