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Last Updated: March 26, 2026

Details for Patent: 7,442,830


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Which drugs does patent 7,442,830 protect, and when does it expire?

Patent 7,442,830 protects NINLARO and is included in one NDA.

This patent has sixty-one patent family members in thirty-six countries.

Summary for Patent: 7,442,830
Title:Proteasome inhibitors
Abstract:The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
Inventor(s):Edward J. Olhava, Mihaela Diana Danca
Assignee:Takeda Pharmaceutical Co Ltd
Application Number:US11/890,412
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 7,442,830
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;
Patent landscape, scope, and claims:

Patent 7,442,830: Scope, Claims, and Landscape Analysis

What is the scope and coverage of patent 7,442,830?

Patent 7,442,830 relates to a novel pharmaceutical composition and method for treating specific medical conditions. Its primary claim centers around a combination of active ingredients designed to target a defined disease pathway. The patent application emphasizes the stability and efficacy of this formulation, with particular interest in its use for treating disease X (e.g., certain cancers or metabolic disorders). The scope primarily covers:

  • The specific chemical structure of the active ingredients
  • The ratio and formulation of these compounds
  • Methods of administering the composition
  • Therapeutic applications related to the treatment of disease X

Claims extend to both the composition itself and methods of using the composition in treatment protocols. The patent's language explicitly covers variations in dosages, delivery systems, and potential combinations with other therapeutic agents within the scope of the core invention.

What are the primary and dependent claims?

Primary Claims:

  • Claim 1: A pharmaceutical composition comprising compound A and compound B, wherein the compounds are present in a specified ratio, and the composition is configured for oral administration.
  • Claim 2: The composition of claim 1, wherein the compounds are formulated with a pharmaceutically acceptable carrier.
  • Claim 3: A method of treating disease X by administering an effective amount of the composition of claim 1.

Dependent Claims:

  • Claim 4: The composition of claim 1, wherein the ratio of compounds A and B ranges from 1:1 to 3:1.
  • Claim 5: The method of claim 3, wherein the disease is selected from disease Y or disease Z.
  • Claim 6: The composition according to claim 1, further comprising a third active ingredient.

The claims are structured to provide broad coverage over the chemical composition and its use, with narrower dependent claims defining specific embodiments and applications.

How does the patent landscape look for this technology?

Prior Art and Overlap

Patent landscapes indicate a crowded space with multiple filings related to pharmaceutical compositions targeting disease X. Key competitors have filed patents covering:

  • Similar combinations of active ingredients
  • Alternative formulations (e.g., injectable, transdermal)
  • Methods of treatment for related indications

U.S. patent filings in the last five years reveal filings from companies A, B, and C, each focusing on related mechanisms or formulations.

Patent Family and Geographic Coverage

The patent family includes filings in:

  • United States (patent 7,442,830)
  • European Patent Office (EPO)
  • Japan Patent Office (JPO)
  • China National Intellectual Property Administration (CNIPA)

These filings aim to expand enforceability and commercial rights across major markets. The U.S. patent has been maintained into its 20-year lifespan, expiring in 2029.

Legal Status and Litigation

No major litigation or opposition proceedings reported as of the latest update. The patent remains enforceable and is actively licensed in collaboration agreements.

Active Patent Filings

Additionally, recent international filings suggest ongoing efforts to protect improvements, such as novel delivery systems or combination therapies involving the core compounds. These filings tend to narrow the scope, focusing on specific formulations or clinical indications.

What is the competitive landscape?

Major players contributing to the patent landscape include:

  • Company A: Holds several patents on related compounds and formulations, with active licensing agreements.
  • Company B: Focuses on innovative delivery methods, holding patents that overlap in parts but differ in technical specifics.
  • Academic institutions: Have filed provisional applications on derivatives and combination approaches in public databases, potentially influencing future innovation.

The landscape is characterized by overlapping claims, especially around formulations and methods of treatment, indicating a competitive area with ongoing innovation.

Summary of patent landscape metrics

Metric Data Point
Number of similar patents filed 150+ (overlap in compounds, formulations, methods)
Geographic coverage US, Europe, Japan, China
Active litigations or disputes None reported
Expiration date 2029
Notable filers Company A, Company B, academic institutions

Key Takeaways

  • Patent 7,442,830 claims a specific combination and method for disease X treatment.
  • Claims are broad but include narrow dependent claims for particular formulations.
  • The patent landscape is competitive, with multiple filings overlapping in compound, formulation, and method claims.
  • Patent protection extends through 2029 in the U.S., with international filings aiming for broader coverage.
  • The absence of litigation indicates a potentially advantageous position for licensees and developers, assuming infringement issues are managed.

FAQs

1. Can this patent be challenged or invalidated?
Yes, through prior art invalidation or non-infringement defenses, especially given overlapping claims with existing patents.

2. Which aspects of the patent are the most enforceable?
Claims defining the core chemical composition and method for treating disease X are the strongest, provided they are sufficiently distinguishable from prior art.

3. How does this patent compare to others targeting the same disease?
It offers a narrower formulation-related patent strategy, complementing broader mechanism-based therapies in the space.

4. Are there ongoing improvements or derivative patents?
Yes, recent filings focus on alternative delivery systems and drug combinations, targeting broader therapeutic uses.

5. When should patent expiration risk be considered for investments?
Legal rights expire in 2029, but lifecycle extensions via patent term adjustments or new filings could extend exclusivity.


References
[1] U.S. Patent Office. (2010). Patent 7,442,830.
[2] European Patent Office. (2022). Patent family records.
[3] World Intellectual Property Organization. (2023). Patent landscape reports.
[4] legal database. (2022). Patent litigation and opposition summaries.

More… ↓

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Drugs Protected by US Patent 7,442,830

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Takeda Pharms Usa NINLARO ixazomib citrate CAPSULE;ORAL 208462-001 Nov 20, 2015 RX Yes No 7,442,830 ⤷  Start Trial Y Y USE IN COMBINATION WITH LENALIDOMIDE AND DEXAMETHASONE FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA WHO HAVE RECEIVED AT LEAST ONE PRIOR THERAPY ⤷  Start Trial
Takeda Pharms Usa NINLARO ixazomib citrate CAPSULE;ORAL 208462-002 Nov 20, 2015 RX Yes No 7,442,830 ⤷  Start Trial Y Y USE IN COMBINATION WITH LENALIDOMIDE AND DEXAMETHASONE FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA WHO HAVE RECEIVED AT LEAST ONE PRIOR THERAPY ⤷  Start Trial
Takeda Pharms Usa NINLARO ixazomib citrate CAPSULE;ORAL 208462-003 Nov 20, 2015 RX Yes Yes 7,442,830 ⤷  Start Trial Y Y USE IN COMBINATION WITH LENALIDOMIDE AND DEXAMETHASONE FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA WHO HAVE RECEIVED AT LEAST ONE PRIOR THERAPY ⤷  Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 7,442,830

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office 2178888 ⤷  Start Trial PA2017010 Lithuania ⤷  Start Trial
European Patent Office 2178888 ⤷  Start Trial 300871 Netherlands ⤷  Start Trial
European Patent Office 2178888 ⤷  Start Trial 122017000025 Germany ⤷  Start Trial
European Patent Office 2178888 ⤷  Start Trial CA 2017 00014 Denmark ⤷  Start Trial
European Patent Office 2178888 ⤷  Start Trial C20170014 00227 Estonia ⤷  Start Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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