Last Updated: August 8, 2026

Details for Patent: 7,404,489

Name: Drug Patent Intelligence for US Patent 7404489
Creator: DrugPatentWatch
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Summary for Patent: 7,404,489

Title:	Cyanocobalamin low viscosity aqueous formulations for intranasal delivery
Abstract:	A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and wherein said solution of cyanocobalamin has a bioavailability of cyanocobalamin when administered intranasally of at least about 7% relative to an intramuscular injection of cyanocobalamin with the proviso that the solution is essentially free of mercury and mercury-containing compounds. The present invention is also directed towards a method for elevating the vitamin B12 levels in the cerebral spinal fluid (CSF) comprising administering intranasally a sufficient amount of a mercury-free cyanocobalamin solution so as to increase the average ratio of vitamin B12 in the CSF to that in the blood serum (B12 CSF/B12 Serum×100) to at least about 1.1 comprising intranasally administering an aqueous solution of a cyanocobalamin, wherein said solution of cyanocobalamin has a bioavailability of at least 7% relative to an intramuscular injection of a cyanocobalamin.
Inventor(s):	Steven C. Quay, Peter C. Aprile, Zenaida O. Go, Anthony P. Sileno
Assignee:	Endo Operations Ltd
Application Number:	US10/814,399
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 7,404,489
Patent Claim Types: see list of patent claims	Composition; Formulation; Compound; Delivery; Device;

Drugs Protected by US Patent 7,404,489

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