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Serving hundreds of leading biopharmaceutical companies globally:

US Department of Justice
Chubb
Moodys
Cantor Fitzgerald
McKinsey
Medtronic
Express Scripts
Merck
UBS

Generated: June 18, 2018

DrugPatentWatch Database Preview

Details for Patent: 7,404,489

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Which drugs does patent 7,404,489 protect, and when does it expire?

Patent 7,404,489 protects NASCOBAL and is included in one NDA.
Summary for Patent: 7,404,489
Title:Cyanocobalamin low viscosity aqueous formulations for intranasal delivery
Abstract:A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and wherein said solution of cyanocobalamin has a bioavailability of cyanocobalamin when administered intranasally of at least about 7% relative to an intramuscular injection of cyanocobalamin with the proviso that the solution is essentially free of mercury and mercury-containing compounds. The present invention is also directed towards a method for elevating the vitamin B12 levels in the cerebral spinal fluid (CSF) comprising administering intranasally a sufficient amount of a mercury-free cyanocobalamin solution so as to increase the average ratio of vitamin B12 in the CSF to that in the blood serum (B12 CSF/B12 Serum.times.100) to at least about 1.1 comprising intranasally administering an aqueous solution of a cyanocobalamin, wherein said solution of cyanocobalamin has a bioavailability of at least 7% relative to an intramuscular injection of a cyanocobalamin.
Inventor(s): Quay; Steven C. (Edmonds, WA), Aprile; Peter C. (East Northport, NY), Go; Zenaida O. (Clifton, NJ), Sileno; Anthony P. (Brookhaven Hamlet, NY)
Assignee: QOL Medical, LLC (Vero Beach, FL)
Application Number:10/814,399
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 7,404,489
Patent Claim Types:
see list of patent claims
Composition; Formulation; Delivery; Device; Compound;

Drugs Protected by US Patent 7,404,489

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Endo Pharms Inc NASCOBAL cyanocobalamin SPRAY, METERED;NASAL 021642-001 Jan 31, 2005 RX Yes Yes ➤ Try a Free Trial ➤ Try a Free Trial Y ➤ Try a Free Trial
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Non-Orange Book US Patents Family Members for Patent 7,404,489

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
8,940,714 Cyanocobalamin low viscosity aqueous formulations for intranasal delivery ➤ Try a Free Trial
7,229,636 Cyanocobalamin low viscosity aqueous formulations for intranasal delivery ➤ Try a Free Trial
9,415,007 Cyanocobalamin low viscosity aqueous formulations for intranasal delivery ➤ Try a Free Trial
8,003,353 Cyanocobalamin low viscosity aqueous formulations for intranasal delivery ➤ Try a Free Trial
Patent No. Title Estimated Patent Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Daiichi Sankyo
Fuji
Queensland Health
UBS
Moodys
Express Scripts
Julphar
AstraZeneca
Deloitte

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