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Generated: October 18, 2017
Which drugs does patent 7,022,330 protect, and when does it expire?
| Title: | Parenteral formulation for epothilone analogs |
| Abstract: | A process for formulating certain epothilone analogs for parenteral administration is disclosed wherein the analog is dissolved in a mixture of at least 50% by volume tertiary-butanol in water, the mixture is lyophilized, the resulting lyophilized product is packaged in one vial with a sufficient amount of solvent comprising anhydrous ethanol and a suitable nonionic surfactant in a second vial. All steps are carried out with protection from light. In use, the contents of the second or diluent vial are added to the lyophilized product and mixed to constitute the epothilone analog and the resulting solution is diluted with a suitable diluent to produce a solution for intravenous injection containing the epothilone analog in a concentration of from about 0.1 mg/mL to about 0.9 mg/mL. A preferred surfactant is polyethoxylated castor oil and a preferred diluent is Lactated Ringer's Injection. |
| Inventor(s): | Bandyopadhyay; Rebanta (Portage, MI), Malloy; Timothy M. (Yardley, PA), Panaggio; Andrea (West Windsor, NJ), Raghavan; Krishnaswamy Srinivas (Cranbury, NJ), Varia; Sailesh Amilal (Princeton Junction, NJ) |
| Assignee: | Bristol-Myers Squibb Company (Princeton, NJ) |
| Application Number: | 10/051,727 |
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Patent Claim Types: see list of patent claims | Use; Compound; Process; Composition; Formulation; |
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
R-pharm Us Llc | IXEMPRA KIT | ixabepilone | INJECTABLE;IV (INFUSION) | 022065-001 | Oct 16, 2007 | RX | Yes | Yes | ► Subscribe | ► Subscribe | Y | ||||
R-pharm Us Llc | IXEMPRA KIT | ixabepilone | INJECTABLE;IV (INFUSION) | 022065-002 | Oct 16, 2007 | RX | Yes | Yes | ► Subscribe | ► Subscribe | Y | ||||
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Serving leading biopharmaceutical companies globally:
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