PROCESSING FOR PRODUCING OF DROSPIRENONE (6.beta., 7.beta., 15.beta., 16.beta.-DIMETHYLENE-3-OXO-17.alpha.-PREGN-4-EN-21, 17-CARBOLACTONE, DRSP) AS WELL AS 7.alpha.-(3-HYDOXY-1-PROPLY)-6.beta., 7.beta.; 15.beta., 16.beta.-DIMETHYLENE-5.beta.-ANDROSTANE-3.beta., 5,17.beta.-TRIOL(ZK 92836) AND 6.beta., 7.beta.; 15.beta., 16.beta.-DIMETHYLENE-5.beta.-HYDROXY
Process for the production of drospirenone (6.beta.,7.beta.; 15.beta.,16.beta.-dimethylene-3-oxo-17.alpha.-pregn-4-ene-21,17-carbolacto ne, DRSP) (1) and 7.alpha.-(3-hydroxy-1-propyl)-6.beta.,7.beta.; 15.beta.,16.beta.-dimethylene-5.beta.-androstane-3.beta.,5,17.beta.-triol (ZK 92836) and 6.beta.,7.beta.; 15.beta.,16.beta.-dimethylene-5.beta.-hydroxy-3-oxo-17.alpha.-androstane-2 1,17-carbolactone (ZK 90965) as intermediate products of the process. ##STR1##
Mohr; Jorg-Thorsten (Berlin, DE), Nickisch; Klaus (Berlin, DE)
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